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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADRA2C
All Species:
13.94
Human Site:
Y46
Identified Species:
30.67
UniProt:
P18825
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18825
NP_000674.2
462
49522
Y46
W
G
P
P
R
G
Q
Y
S
A
G
A
V
A
G
Chimpanzee
Pan troglodytes
Q9N298
422
46153
L46
T
S
L
L
L
G
T
L
I
F
C
A
V
L
G
Rhesus Macaque
Macaca mulatta
XP_001114432
408
42792
Y44
W
G
P
P
R
G
Q
Y
S
A
G
A
V
A
G
Dog
Lupus familis
XP_545911
714
73976
P47
P
G
A
A
W
G
P
P
P
G
Q
Y
S
A
G
Cat
Felis silvestris
Mouse
Mus musculus
Q01337
458
49888
Y46
W
V
P
P
P
G
Q
Y
S
A
G
A
V
A
G
Rat
Rattus norvegicus
P22086
458
49846
Y46
W
G
P
P
P
G
Q
Y
S
A
G
A
V
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519776
218
24278
Chicken
Gallus gallus
XP_426355
614
69002
H140
A
S
P
G
G
T
E
H
A
R
G
G
G
A
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q90WY6
432
49119
F44
G
L
A
G
L
V
S
F
L
I
L
F
T
I
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22270
601
64656
T70
V
E
G
L
T
T
V
T
A
A
L
S
T
A
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001200819
471
53401
P44
V
S
P
Q
P
Y
P
P
S
G
Y
G
L
T
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
33.9
80.3
59.6
N.A.
92.8
93
N.A.
35.9
53.7
N.A.
58.4
N.A.
32.7
N.A.
N.A.
33.3
Protein Similarity:
100
50
80.9
61.6
N.A.
93.5
93.7
N.A.
39.1
60.2
N.A.
70.1
N.A.
47.5
N.A.
N.A.
52.2
P-Site Identity:
100
26.6
100
26.6
N.A.
86.6
93.3
N.A.
0
20
N.A.
0
N.A.
13.3
N.A.
N.A.
13.3
P-Site Similarity:
100
26.6
100
26.6
N.A.
86.6
93.3
N.A.
0
40
N.A.
6.6
N.A.
26.6
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
19
10
0
0
0
0
19
46
0
46
0
64
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
10
0
0
0
0
10
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
10
0
10
0
10
0
0
0
% F
% Gly:
10
37
10
19
10
55
0
0
0
19
46
19
10
0
55
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
10
0
0
0
10
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
10
19
19
0
0
10
10
0
19
0
10
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
0
55
37
28
0
19
19
10
0
0
0
0
0
0
% P
% Gln:
0
0
0
10
0
0
37
0
0
0
10
0
0
0
10
% Q
% Arg:
0
0
0
0
19
0
0
0
0
10
0
0
0
0
19
% R
% Ser:
0
28
0
0
0
0
10
0
46
0
0
10
10
0
0
% S
% Thr:
10
0
0
0
10
19
10
10
0
0
0
0
19
10
0
% T
% Val:
19
10
0
0
0
10
10
0
0
0
0
0
46
0
10
% V
% Trp:
37
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
37
0
0
10
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _