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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LIG1 All Species: 30.61
Human Site: S388 Identified Species: 61.21
UniProt: P18858 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P18858 NP_000225.1 919 101736 S388 L V A E N S R S T Q R L M L P
Chimpanzee Pan troglodytes XP_524321 919 101662 S388 L V A E N S R S T Q R L M L P
Rhesus Macaque Macaca mulatta XP_001111346 919 101454 S388 L V A E N S R S T Q R L M L P
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P37913 916 102271 S386 L V A E N S R S T Q R L M L P
Rat Rattus norvegicus Q9JHY8 918 102463 S388 L V A E N S R S T Q R L M L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis P51892 1070 120215 S541 L V A E S S R S N Q R T M F T
Zebra Danio Brachydanio rerio NP_001119860 1058 118776 S530 L V A E S S R S N Q R M M F A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W1H4 747 84700 I249 V F R K L R E I A K L S G Q S
Honey Bee Apis mellifera XP_392286 861 97795 Y349 P L T V S S V Y T R L K E I A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001180844 967 108403 S439 L V A E S S R S T Q R T M F T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42572 790 87722 V292 E P L T V V K V F D T F R Q I
Baker's Yeast Sacchar. cerevisiae P04819 755 84810 K257 Q P T M F K P K P L T V G E V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 98.2 N.A. N.A. 84 81.3 N.A. N.A. N.A. 56.9 56.1 N.A. 44 46 N.A. 48.5
Protein Similarity: 100 99.4 98.8 N.A. N.A. 89.3 87.8 N.A. N.A. N.A. 71.1 68.6 N.A. 60.2 65.7 N.A. 66.2
P-Site Identity: 100 100 100 N.A. N.A. 100 100 N.A. N.A. N.A. 66.6 66.6 N.A. 0 13.3 N.A. 73.3
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. N.A. N.A. 73.3 80 N.A. 20 40 N.A. 80
Percent
Protein Identity: N.A. N.A. N.A. 40.3 36 N.A.
Protein Similarity: N.A. N.A. N.A. 58.3 53.6 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 67 0 0 0 0 0 9 0 0 0 0 0 17 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % D
% Glu: 9 0 0 67 0 0 9 0 0 0 0 0 9 9 0 % E
% Phe: 0 9 0 0 9 0 0 0 9 0 0 9 0 25 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 17 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 9 0 0 0 0 0 9 9 % I
% Lys: 0 0 0 9 0 9 9 9 0 9 0 9 0 0 0 % K
% Leu: 67 9 9 0 9 0 0 0 0 9 17 42 0 42 0 % L
% Met: 0 0 0 9 0 0 0 0 0 0 0 9 67 0 0 % M
% Asn: 0 0 0 0 42 0 0 0 17 0 0 0 0 0 0 % N
% Pro: 9 17 0 0 0 0 9 0 9 0 0 0 0 0 42 % P
% Gln: 9 0 0 0 0 0 0 0 0 67 0 0 0 17 0 % Q
% Arg: 0 0 9 0 0 9 67 0 0 9 67 0 9 0 0 % R
% Ser: 0 0 0 0 34 75 0 67 0 0 0 9 0 0 9 % S
% Thr: 0 0 17 9 0 0 0 0 59 0 17 17 0 0 17 % T
% Val: 9 67 0 9 9 9 9 9 0 0 0 9 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _