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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDC All Species: 19.09
Human Site: S46 Identified Species: 42
UniProt: P19113 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P19113 NP_002103.2 662 74141 S46 L R A Q L P E S A P E D P D S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001114184 662 74119 S46 L R A Q L P E S A P E D P D S
Dog Lupus familis XP_544676 682 76246 S65 L R A Q L P E S A P E E P D S
Cat Felis silvestris
Mouse Mus musculus P23738 662 74000 S53 L R A Q L P A S A P E E P D S
Rat Rattus norvegicus P16453 656 73617 S49 L R A Q I P S S A P E E P D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_413833 664 74607 M48 Q L P D S A P M D P D S W D N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001096063 594 67355 Y48 L L P S S A P Y E P E D W S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q05733 847 94017 I48 L L P E S A P I E G E P W P K
Honey Bee Apis mellifera XP_392129 718 80063 V48 I L P S S A P V N G E S W E D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789367 562 63469 D19 E M V D Y V A D Y L S T I R S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RY79 490 54405
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98 89.3 N.A. 86.8 85.8 N.A. N.A. 76 N.A. 54.8 N.A. 42.7 48.1 N.A. 50.3
Protein Similarity: 100 N.A. 98.9 93.1 N.A. 92.3 91.5 N.A. N.A. 84.1 N.A. 68.4 N.A. 56.9 62.2 N.A. 64.5
P-Site Identity: 100 N.A. 100 93.3 N.A. 86.6 80 N.A. N.A. 13.3 N.A. 26.6 N.A. 13.3 6.6 N.A. 6.6
P-Site Similarity: 100 N.A. 100 100 N.A. 93.3 93.3 N.A. N.A. 26.6 N.A. 33.3 N.A. 20 20 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 33.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 49.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 0 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 46 0 0 37 19 0 46 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 19 0 0 0 10 10 0 10 28 0 55 10 % D
% Glu: 10 0 0 10 0 0 28 0 19 0 73 28 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 19 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 10 0 0 10 0 0 0 0 10 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % K
% Leu: 64 37 0 0 37 0 0 0 0 10 0 0 0 0 0 % L
% Met: 0 10 0 0 0 0 0 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 10 % N
% Pro: 0 0 37 0 0 46 37 0 0 64 0 10 46 10 0 % P
% Gln: 10 0 0 46 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 46 0 0 0 0 0 0 0 0 0 0 0 10 0 % R
% Ser: 0 0 0 19 37 0 10 46 0 0 10 19 0 10 55 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 10 % T
% Val: 0 0 10 0 0 10 0 10 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 37 0 0 % W
% Tyr: 0 0 0 0 10 0 0 10 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _