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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDC
All Species:
4.24
Human Site:
S492
Identified Species:
9.33
UniProt:
P19113
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19113
NP_002103.2
662
74141
S492
P
R
V
G
N
L
I
S
Q
I
R
G
A
R
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114184
662
74119
P492
P
R
V
G
N
L
I
P
Q
I
R
G
A
R
A
Dog
Lupus familis
XP_544676
682
76246
P511
P
Q
V
G
N
L
I
P
Q
T
T
G
P
R
A
Cat
Felis silvestris
Mouse
Mus musculus
P23738
662
74000
P499
P
R
A
K
N
V
I
P
P
P
P
G
T
R
G
Rat
Rattus norvegicus
P16453
656
73617
P495
P
R
A
K
N
L
I
P
P
P
V
T
R
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_413833
664
74607
P492
S
G
D
E
A
K
I
P
N
M
I
S
E
P
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001096063
594
67355
S451
Q
D
I
R
R
D
W
S
L
I
Q
Q
A
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05733
847
94017
S636
P
E
H
A
H
S
L
S
T
P
S
R
S
C
S
Honey Bee
Apis mellifera
XP_392129
718
80063
S507
T
S
L
L
L
A
N
S
P
M
S
P
K
I
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789367
562
63469
G419
F
R
L
K
G
P
N
G
L
T
Q
E
L
L
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY79
490
54405
N347
K
N
K
A
S
Q
A
N
L
V
V
D
Y
K
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98
89.3
N.A.
86.8
85.8
N.A.
N.A.
76
N.A.
54.8
N.A.
42.7
48.1
N.A.
50.3
Protein Similarity:
100
N.A.
98.9
93.1
N.A.
92.3
91.5
N.A.
N.A.
84.1
N.A.
68.4
N.A.
56.9
62.2
N.A.
64.5
P-Site Identity:
100
N.A.
93.3
66.6
N.A.
40
33.3
N.A.
N.A.
6.6
N.A.
20
N.A.
13.3
6.6
N.A.
6.6
P-Site Similarity:
100
N.A.
93.3
73.3
N.A.
46.6
40
N.A.
N.A.
20
N.A.
33.3
N.A.
40
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
19
19
10
10
10
0
0
0
0
0
28
10
28
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% C
% Asp:
0
10
10
0
0
10
0
0
0
0
0
10
0
10
10
% D
% Glu:
0
10
0
10
0
0
0
0
0
0
0
10
10
0
0
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
28
10
0
0
10
0
0
0
37
0
0
10
% G
% His:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
55
0
0
28
10
0
0
10
0
% I
% Lys:
10
0
10
28
0
10
0
0
0
0
0
0
10
10
0
% K
% Leu:
0
0
19
10
10
37
10
0
28
0
0
0
10
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
0
% M
% Asn:
0
10
0
0
46
0
19
10
10
0
0
0
0
0
0
% N
% Pro:
55
0
0
0
0
10
0
46
28
28
10
10
10
10
0
% P
% Gln:
10
10
0
0
0
10
0
0
28
0
19
10
0
0
0
% Q
% Arg:
0
46
0
10
10
0
0
0
0
0
19
10
10
37
19
% R
% Ser:
10
10
0
0
10
10
0
37
0
0
19
10
10
0
28
% S
% Thr:
10
0
0
0
0
0
0
0
10
19
10
10
10
0
0
% T
% Val:
0
0
28
0
0
10
0
0
0
10
19
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _