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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDC
All Species:
16.36
Human Site:
S554
Identified Species:
36
UniProt:
P19113
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19113
NP_002103.2
662
74141
S554
D
P
V
D
D
C
F
S
E
E
A
P
D
A
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114184
662
74119
S554
D
P
V
D
D
C
F
S
E
E
A
P
D
A
T
Dog
Lupus familis
XP_544676
682
76246
S574
P
L
D
D
D
C
F
S
E
E
T
P
D
V
T
Cat
Felis silvestris
Mouse
Mus musculus
P23738
662
74000
S554
D
P
F
D
D
C
F
S
E
E
A
P
N
T
T
Rat
Rattus norvegicus
P16453
656
73617
S547
D
P
F
D
D
C
F
S
E
E
A
S
D
T
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_413833
664
74607
V556
D
D
C
F
P
E
D
V
Q
D
V
T
K
H
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001096063
594
67355
R494
T
E
P
M
L
D
Q
R
L
V
R
Q
G
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05733
847
94017
S747
I
A
T
P
T
R
E
S
P
E
D
P
D
W
P
Honey Bee
Apis mellifera
XP_392129
718
80063
L589
E
M
A
T
E
L
P
L
Q
E
D
E
D
V
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789367
562
63469
L462
E
T
T
E
D
D
I
L
E
D
W
R
L
I
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY79
490
54405
L390
Y
I
R
N
H
I
K
L
A
K
E
F
E
Q
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98
89.3
N.A.
86.8
85.8
N.A.
N.A.
76
N.A.
54.8
N.A.
42.7
48.1
N.A.
50.3
Protein Similarity:
100
N.A.
98.9
93.1
N.A.
92.3
91.5
N.A.
N.A.
84.1
N.A.
68.4
N.A.
56.9
62.2
N.A.
64.5
P-Site Identity:
100
N.A.
100
66.6
N.A.
80
80
N.A.
N.A.
6.6
N.A.
0
N.A.
26.6
13.3
N.A.
13.3
P-Site Similarity:
100
N.A.
100
66.6
N.A.
86.6
80
N.A.
N.A.
20
N.A.
0
N.A.
26.6
33.3
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
0
0
0
0
0
10
0
37
0
0
19
0
% A
% Cys:
0
0
10
0
0
46
0
0
0
0
0
0
0
0
0
% C
% Asp:
46
10
10
46
55
19
10
0
0
19
19
0
55
0
0
% D
% Glu:
19
10
0
10
10
10
10
0
55
64
10
10
10
0
0
% E
% Phe:
0
0
19
10
0
0
46
0
0
0
0
10
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
10
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% H
% Ile:
10
10
0
0
0
10
10
0
0
0
0
0
0
10
0
% I
% Lys:
0
0
0
0
0
0
10
0
0
10
0
0
10
0
10
% K
% Leu:
0
10
0
0
10
10
0
28
10
0
0
0
10
0
10
% L
% Met:
0
10
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
10
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
10
37
10
10
10
0
10
0
10
0
0
46
0
0
10
% P
% Gln:
0
0
0
0
0
0
10
0
19
0
0
10
0
19
10
% Q
% Arg:
0
0
10
0
0
10
0
10
0
0
10
10
0
0
10
% R
% Ser:
0
0
0
0
0
0
0
55
0
0
0
10
0
0
0
% S
% Thr:
10
10
19
10
10
0
0
0
0
0
10
10
0
19
46
% T
% Val:
0
0
19
0
0
0
0
10
0
10
10
0
0
19
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _