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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDC
All Species:
18.48
Human Site:
S603
Identified Species:
40.67
UniProt:
P19113
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19113
NP_002103.2
662
74141
S603
K
P
L
P
T
E
A
S
V
K
N
G
G
S
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114184
662
74119
S603
K
P
L
P
T
E
A
S
V
K
N
G
G
S
S
Dog
Lupus familis
XP_544676
682
76246
S623
K
P
L
P
T
D
G
S
V
K
N
G
G
S
S
Cat
Felis silvestris
Mouse
Mus musculus
P23738
662
74000
S603
K
S
L
P
A
D
A
S
L
K
N
G
G
S
F
Rat
Rattus norvegicus
P16453
656
73617
S596
K
S
P
P
P
D
A
S
V
K
H
G
G
F
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_413833
664
74607
S605
C
N
P
K
T
T
D
S
D
Q
K
E
P
H
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001096063
594
67355
L543
E
R
P
Q
H
R
R
L
L
K
F
X
S
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05733
847
94017
S796
T
P
T
P
T
P
M
S
S
L
D
E
L
V
T
Honey Bee
Apis mellifera
XP_392129
718
80063
R638
K
R
Q
T
S
K
S
R
S
N
Y
T
V
N
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789367
562
63469
R511
A
T
H
V
L
K
N
R
K
E
I
Y
I
E
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY79
490
54405
A439
R
N
R
E
L
L
D
A
V
N
S
S
G
K
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98
89.3
N.A.
86.8
85.8
N.A.
N.A.
76
N.A.
54.8
N.A.
42.7
48.1
N.A.
50.3
Protein Similarity:
100
N.A.
98.9
93.1
N.A.
92.3
91.5
N.A.
N.A.
84.1
N.A.
68.4
N.A.
56.9
62.2
N.A.
64.5
P-Site Identity:
100
N.A.
100
86.6
N.A.
66.6
53.3
N.A.
N.A.
13.3
N.A.
6.6
N.A.
26.6
6.6
N.A.
0
P-Site Similarity:
100
N.A.
100
93.3
N.A.
80
66.6
N.A.
N.A.
26.6
N.A.
20
N.A.
40
33.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
10
0
37
10
0
0
0
0
0
0
10
% A
% Cys:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
28
19
0
10
0
10
0
0
0
0
% D
% Glu:
10
0
0
10
0
19
0
0
0
10
0
19
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
19
% F
% Gly:
0
0
0
0
0
0
10
0
0
0
0
46
55
0
10
% G
% His:
0
0
10
0
10
0
0
0
0
0
10
0
0
10
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% I
% Lys:
55
0
0
10
0
19
0
0
10
55
10
0
0
10
0
% K
% Leu:
0
0
37
0
19
10
0
10
19
10
0
0
10
0
10
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
19
0
0
0
0
10
0
0
19
37
0
0
10
10
% N
% Pro:
0
37
28
55
10
10
0
0
0
0
0
0
10
0
10
% P
% Gln:
0
0
10
10
0
0
0
0
0
10
0
0
0
0
0
% Q
% Arg:
10
19
10
0
0
10
10
19
0
0
0
0
0
0
0
% R
% Ser:
0
19
0
0
10
0
10
64
19
0
10
10
10
37
28
% S
% Thr:
10
10
10
10
46
10
0
0
0
0
0
10
0
0
10
% T
% Val:
0
0
0
10
0
0
0
0
46
0
0
0
10
19
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _