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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDC
All Species:
20.61
Human Site:
S616
Identified Species:
45.33
UniProt:
P19113
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19113
NP_002103.2
662
74141
S616
S
S
R
V
R
I
F
S
R
F
P
E
D
M
M
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114184
662
74119
S616
S
S
R
V
R
I
F
S
R
F
P
E
E
M
M
Dog
Lupus familis
XP_544676
682
76246
S636
S
S
R
A
R
F
F
S
R
F
P
E
E
M
M
Cat
Felis silvestris
Mouse
Mus musculus
P23738
662
74000
S616
S
F
R
A
R
I
F
S
G
F
P
E
Q
M
M
Rat
Rattus norvegicus
P16453
656
73617
S609
F
F
R
A
R
I
F
S
G
F
P
E
E
M
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_413833
664
74607
S618
H
A
N
G
R
I
L
S
R
L
P
E
E
V
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001096063
594
67355
W556
V
P
S
L
A
Q
V
W
A
Q
C
G
M
Q
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05733
847
94017
F809
V
T
P
L
L
L
S
F
A
S
P
S
Q
P
M
Honey Bee
Apis mellifera
XP_392129
718
80063
S651
N
G
S
V
K
I
G
S
Q
D
C
S
N
T
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789367
562
63469
K524
E
N
N
N
E
D
K
K
E
E
D
E
E
N
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY79
490
54405
A452
K
L
F
M
S
H
T
A
L
S
G
K
I
V
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98
89.3
N.A.
86.8
85.8
N.A.
N.A.
76
N.A.
54.8
N.A.
42.7
48.1
N.A.
50.3
Protein Similarity:
100
N.A.
98.9
93.1
N.A.
92.3
91.5
N.A.
N.A.
84.1
N.A.
68.4
N.A.
56.9
62.2
N.A.
64.5
P-Site Identity:
100
N.A.
93.3
80
N.A.
73.3
66.6
N.A.
N.A.
46.6
N.A.
0
N.A.
13.3
20
N.A.
6.6
P-Site Similarity:
100
N.A.
100
86.6
N.A.
73.3
73.3
N.A.
N.A.
66.6
N.A.
6.6
N.A.
33.3
53.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
28
10
0
0
10
19
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
19
0
0
0
0
% C
% Asp:
0
0
0
0
0
10
0
0
0
10
10
0
10
0
0
% D
% Glu:
10
0
0
0
10
0
0
0
10
10
0
64
46
0
10
% E
% Phe:
10
19
10
0
0
10
46
10
0
46
0
0
0
0
0
% F
% Gly:
0
10
0
10
0
0
10
0
19
0
10
10
0
0
0
% G
% His:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
55
0
0
0
0
0
0
10
0
0
% I
% Lys:
10
0
0
0
10
0
10
10
0
0
0
10
0
0
0
% K
% Leu:
0
10
0
19
10
10
10
0
10
10
0
0
0
0
19
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
10
46
64
% M
% Asn:
10
10
19
10
0
0
0
0
0
0
0
0
10
10
0
% N
% Pro:
0
10
10
0
0
0
0
0
0
0
64
0
0
10
0
% P
% Gln:
0
0
0
0
0
10
0
0
10
10
0
0
19
10
10
% Q
% Arg:
0
0
46
0
55
0
0
0
37
0
0
0
0
0
0
% R
% Ser:
37
28
19
0
10
0
10
64
0
19
0
19
0
0
0
% S
% Thr:
0
10
0
0
0
0
10
0
0
0
0
0
0
10
0
% T
% Val:
19
0
0
28
0
0
10
0
0
0
0
0
0
19
0
% V
% Trp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _