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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDC
All Species:
26.36
Human Site:
S638
Identified Species:
58
UniProt:
P19113
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19113
NP_002103.2
662
74141
S638
K
K
L
I
K
F
Y
S
V
P
S
F
P
E
C
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114184
662
74119
S638
K
K
L
I
K
F
Y
S
V
P
S
F
P
E
C
Dog
Lupus familis
XP_544676
682
76246
S658
K
K
L
I
K
F
Y
S
V
P
S
F
P
E
C
Cat
Felis silvestris
Mouse
Mus musculus
P23738
662
74000
S638
K
K
L
I
K
F
Y
S
V
P
S
F
P
E
C
Rat
Rattus norvegicus
P16453
656
73617
S631
K
K
L
I
K
F
Y
S
V
P
S
F
P
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_413833
664
74607
S640
K
K
L
I
K
F
Y
S
V
P
S
F
S
E
C
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001096063
594
67355
S578
G
L
I
T
S
R
A
S
C
F
T
C
P
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05733
847
94017
S831
E
G
Q
R
E
Q
G
S
D
S
D
A
T
V
C
Honey Bee
Apis mellifera
XP_392129
718
80063
T673
G
N
L
P
R
S
E
T
I
A
A
I
G
H
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789367
562
63469
A546
G
M
N
V
E
E
K
A
N
G
P
P
I
F
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY79
490
54405
K474
L
T
E
E
K
H
V
K
E
A
W
K
I
I
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98
89.3
N.A.
86.8
85.8
N.A.
N.A.
76
N.A.
54.8
N.A.
42.7
48.1
N.A.
50.3
Protein Similarity:
100
N.A.
98.9
93.1
N.A.
92.3
91.5
N.A.
N.A.
84.1
N.A.
68.4
N.A.
56.9
62.2
N.A.
64.5
P-Site Identity:
100
N.A.
100
100
N.A.
100
100
N.A.
N.A.
93.3
N.A.
13.3
N.A.
13.3
6.6
N.A.
0
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
N.A.
93.3
N.A.
26.6
N.A.
26.6
33.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
10
10
0
19
10
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
64
% C
% Asp:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% D
% Glu:
10
0
10
10
19
10
10
0
10
0
0
0
0
55
0
% E
% Phe:
0
0
0
0
0
55
0
0
0
10
0
55
0
10
0
% F
% Gly:
28
10
0
0
0
0
10
0
0
10
0
0
10
0
0
% G
% His:
0
0
0
0
0
10
0
0
0
0
0
0
0
10
0
% H
% Ile:
0
0
10
55
0
0
0
0
10
0
0
10
19
10
0
% I
% Lys:
55
55
0
0
64
0
10
10
0
0
0
10
0
0
10
% K
% Leu:
10
10
64
0
0
0
0
0
0
0
0
0
0
0
10
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
10
0
0
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
0
0
0
55
10
10
55
10
0
% P
% Gln:
0
0
10
0
0
10
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
0
0
10
10
10
0
0
0
0
0
0
0
0
10
% R
% Ser:
0
0
0
0
10
10
0
73
0
10
55
0
10
0
0
% S
% Thr:
0
10
0
10
0
0
0
10
0
0
10
0
10
0
0
% T
% Val:
0
0
0
10
0
0
10
0
55
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
55
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _