KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDC
All Species:
30.91
Human Site:
T456
Identified Species:
68
UniProt:
P19113
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19113
NP_002103.2
662
74141
T456
T
V
T
S
Q
F
T
T
R
D
D
I
L
R
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114184
662
74119
T456
T
V
T
S
Q
F
T
T
R
D
D
I
L
R
D
Dog
Lupus familis
XP_544676
682
76246
T475
T
V
T
S
Q
F
T
T
R
D
D
I
L
R
D
Cat
Felis silvestris
Mouse
Mus musculus
P23738
662
74000
T463
T
V
T
S
Q
F
T
T
K
E
D
I
L
R
D
Rat
Rattus norvegicus
P16453
656
73617
T459
T
V
T
S
Q
F
T
T
K
D
D
I
L
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_413833
664
74607
T455
T
V
T
S
Q
F
T
T
R
E
D
I
L
Q
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001096063
594
67355
S416
L
L
R
K
L
T
R
S
G
R
M
F
L
I
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05733
847
94017
T455
T
I
T
S
T
H
T
T
L
D
D
I
V
K
D
Honey Bee
Apis mellifera
XP_392129
718
80063
T455
T
V
T
S
T
N
T
T
N
E
D
I
L
R
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789367
562
63469
R384
E
H
V
R
R
G
V
R
L
G
H
Y
F
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY79
490
54405
L312
M
N
A
H
K
W
F
L
T
N
F
D
C
S
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98
89.3
N.A.
86.8
85.8
N.A.
N.A.
76
N.A.
54.8
N.A.
42.7
48.1
N.A.
50.3
Protein Similarity:
100
N.A.
98.9
93.1
N.A.
92.3
91.5
N.A.
N.A.
84.1
N.A.
68.4
N.A.
56.9
62.2
N.A.
64.5
P-Site Identity:
100
N.A.
100
100
N.A.
86.6
93.3
N.A.
N.A.
86.6
N.A.
6.6
N.A.
60
73.3
N.A.
0
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
N.A.
100
N.A.
20
N.A.
80
80
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
46
73
10
0
0
73
% D
% Glu:
10
0
0
0
0
0
0
0
0
28
0
0
0
10
0
% E
% Phe:
0
0
0
0
0
55
10
0
0
0
10
10
10
0
0
% F
% Gly:
0
0
0
0
0
10
0
0
10
10
0
0
0
0
0
% G
% His:
0
10
0
10
0
10
0
0
0
0
10
0
0
0
0
% H
% Ile:
0
10
0
0
0
0
0
0
0
0
0
73
0
10
0
% I
% Lys:
0
0
0
10
10
0
0
0
19
0
0
0
0
10
10
% K
% Leu:
10
10
0
0
10
0
0
10
19
0
0
0
73
0
10
% L
% Met:
10
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
10
0
0
0
10
0
0
10
10
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
0
55
0
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
10
10
10
0
10
10
37
10
0
0
0
55
0
% R
% Ser:
0
0
0
73
0
0
0
10
0
0
0
0
0
10
0
% S
% Thr:
73
0
73
0
19
10
73
73
10
0
0
0
0
0
0
% T
% Val:
0
64
10
0
0
0
10
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _