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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDC
All Species:
32.73
Human Site:
Y188
Identified Species:
72
UniProt:
P19113
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19113
NP_002103.2
662
74141
Y188
L
N
A
R
L
V
A
Y
A
S
D
Q
A
H
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114184
662
74119
Y188
L
N
A
R
L
V
A
Y
A
S
D
Q
A
H
S
Dog
Lupus familis
XP_544676
682
76246
Y207
L
N
A
R
L
I
A
Y
A
S
D
Q
A
H
S
Cat
Felis silvestris
Mouse
Mus musculus
P23738
662
74000
Y195
L
N
A
R
L
V
A
Y
T
S
D
Q
A
H
S
Rat
Rattus norvegicus
P16453
656
73617
Y191
L
N
A
R
L
V
A
Y
A
S
D
Q
A
H
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_413833
664
74607
Y187
L
N
S
R
L
I
A
Y
A
S
D
Q
A
H
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001096063
594
67355
T175
M
K
S
E
A
T
H
T
D
T
D
E
S
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05733
847
94017
Y187
I
N
A
R
L
V
A
Y
C
S
D
Q
A
H
S
Honey Bee
Apis mellifera
XP_392129
718
80063
Y187
I
N
S
R
L
V
A
Y
C
S
D
Q
A
H
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789367
562
63469
V144
T
T
N
T
G
G
G
V
L
Q
G
T
M
S
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY79
490
54405
R72
D
Q
V
L
D
D
V
R
A
K
I
L
P
G
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98
89.3
N.A.
86.8
85.8
N.A.
N.A.
76
N.A.
54.8
N.A.
42.7
48.1
N.A.
50.3
Protein Similarity:
100
N.A.
98.9
93.1
N.A.
92.3
91.5
N.A.
N.A.
84.1
N.A.
68.4
N.A.
56.9
62.2
N.A.
64.5
P-Site Identity:
100
N.A.
100
93.3
N.A.
93.3
100
N.A.
N.A.
86.6
N.A.
6.6
N.A.
86.6
80
N.A.
0
P-Site Similarity:
100
N.A.
100
100
N.A.
93.3
100
N.A.
N.A.
100
N.A.
40
N.A.
93.3
93.3
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
55
0
10
0
73
0
55
0
0
0
73
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
19
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
10
10
0
0
10
0
82
0
0
0
0
% D
% Glu:
0
0
0
10
0
0
0
0
0
0
0
10
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
10
10
10
0
0
0
10
0
0
10
0
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
0
73
0
% H
% Ile:
19
0
0
0
0
19
0
0
0
0
10
0
0
0
0
% I
% Lys:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% K
% Leu:
55
0
0
10
73
0
0
0
10
0
0
10
0
0
10
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
73
10
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% P
% Gln:
0
10
0
0
0
0
0
0
0
10
0
73
0
0
0
% Q
% Arg:
0
0
0
73
0
0
0
10
0
0
0
0
0
0
0
% R
% Ser:
0
0
28
0
0
0
0
0
0
73
0
0
10
10
73
% S
% Thr:
10
10
0
10
0
10
0
10
10
10
0
10
0
0
0
% T
% Val:
0
0
10
0
0
55
10
10
0
0
0
0
0
10
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
73
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _