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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDC
All Species:
10
Human Site:
Y7
Identified Species:
22
UniProt:
P19113
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19113
NP_002103.2
662
74141
Y7
_
M
M
E
P
E
E
Y
R
E
R
G
R
E
M
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114184
662
74119
Y7
_
M
M
E
P
E
E
Y
R
E
R
G
R
E
M
Dog
Lupus familis
XP_544676
682
76246
E26
L
V
S
H
R
E
R
E
R
E
R
G
K
E
M
Cat
Felis silvestris
Mouse
Mus musculus
P23738
662
74000
Y14
Y
R
E
Y
R
E
Y
Y
R
A
R
G
K
E
M
Rat
Rattus norvegicus
P16453
656
73617
Y10
E
P
S
E
Y
H
E
Y
Q
A
R
G
K
E
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_413833
664
74607
R9
E
P
E
E
Y
R
R
R
G
K
E
M
V
D
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001096063
594
67355
R9
Q
P
Q
E
Y
M
L
R
G
K
E
M
V
E
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q05733
847
94017
R9
D
F
K
E
Y
R
Q
R
G
K
E
M
V
D
Y
Honey Bee
Apis mellifera
XP_392129
718
80063
H9
N
L
E
E
Y
R
K
H
G
K
E
M
V
D
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789367
562
63469
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY79
490
54405
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98
89.3
N.A.
86.8
85.8
N.A.
N.A.
76
N.A.
54.8
N.A.
42.7
48.1
N.A.
50.3
Protein Similarity:
100
N.A.
98.9
93.1
N.A.
92.3
91.5
N.A.
N.A.
84.1
N.A.
68.4
N.A.
56.9
62.2
N.A.
64.5
P-Site Identity:
100
N.A.
100
46.6
N.A.
46.6
46.6
N.A.
N.A.
6.6
N.A.
13.3
N.A.
6.6
6.6
N.A.
0
P-Site Similarity:
100
N.A.
100
60
N.A.
60
60
N.A.
N.A.
20
N.A.
20
N.A.
26.6
40
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
0
0
0
0
0
0
0
0
28
0
% D
% Glu:
19
0
28
64
0
37
28
10
0
28
37
0
0
55
0
% E
% Phe:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
37
0
0
46
0
0
0
% G
% His:
0
0
0
10
0
10
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
10
0
0
0
10
0
0
37
0
0
28
0
0
% K
% Leu:
10
10
0
0
0
0
10
0
0
0
0
0
0
0
0
% L
% Met:
0
19
19
0
0
10
0
0
0
0
0
37
0
0
46
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
28
0
0
19
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
10
0
10
0
0
0
10
0
10
0
0
0
0
0
0
% Q
% Arg:
0
10
0
0
19
28
19
28
37
0
46
0
19
0
0
% R
% Ser:
0
0
19
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
10
0
0
0
0
0
0
0
0
0
0
37
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
10
46
0
10
37
0
0
0
0
0
0
37
% Y
% Spaces:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _