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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG1
All Species:
20
Human Site:
Y338
Identified Species:
40
UniProt:
P19174
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19174
NP_002651.2
1290
148532
Y338
I
S
S
S
H
N
T
Y
L
T
G
D
Q
F
S
Chimpanzee
Pan troglodytes
XP_514650
1630
185027
Y678
I
S
S
S
H
N
T
Y
L
T
G
D
Q
F
S
Rhesus Macaque
Macaca mulatta
XP_001087295
1291
148567
Y338
I
S
S
S
H
N
T
Y
L
T
G
D
Q
F
S
Dog
Lupus familis
XP_542998
1249
143812
W329
R
C
I
E
L
D
C
W
D
G
P
D
G
M
P
Cat
Felis silvestris
Mouse
Mus musculus
Q62077
1302
149650
Y338
I
S
S
S
H
N
T
Y
L
T
G
D
Q
F
S
Rat
Rattus norvegicus
P10686
1290
148530
Y338
I
S
S
S
H
N
T
Y
L
T
G
D
Q
F
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q2VRL0
637
72514
Frog
Xenopus laevis
Q32NH8
758
87399
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13217
1095
124845
T236
E
E
L
F
T
S
I
T
K
G
K
Q
D
F
I
Honey Bee
Apis mellifera
XP_624101
1134
132613
R275
S
S
C
Q
A
Y
V
R
A
L
R
T
G
C
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
T81
V
F
G
D
T
L
L
T
Q
P
I
D
R
D
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79
99.5
93.2
N.A.
95.3
96.9
N.A.
N.A.
21.4
21.7
21.8
N.A.
21.4
45.1
N.A.
35.1
Protein Similarity:
100
79
99.7
94.5
N.A.
96.7
98.2
N.A.
N.A.
32.4
37.3
36.3
N.A.
40
62
N.A.
50
P-Site Identity:
100
100
100
6.6
N.A.
100
100
N.A.
N.A.
0
0
0
N.A.
6.6
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
N.A.
0
0
0
N.A.
13.3
6.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
0
9
0
0
0
0
0
9
% A
% Cys:
0
9
9
0
0
0
9
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
9
0
9
0
0
9
0
0
59
9
9
0
% D
% Glu:
9
9
0
9
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
9
0
9
0
0
0
0
0
0
0
0
0
50
0
% F
% Gly:
0
0
9
0
0
0
0
0
0
17
42
0
17
0
0
% G
% His:
0
0
0
0
42
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
42
0
9
0
0
0
9
0
0
0
9
0
0
0
9
% I
% Lys:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% K
% Leu:
0
0
9
0
9
9
9
0
42
9
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
0
0
0
0
42
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
9
9
0
0
0
9
% P
% Gln:
0
0
0
9
0
0
0
0
9
0
0
9
42
0
0
% Q
% Arg:
9
0
0
0
0
0
0
9
0
0
9
0
9
0
9
% R
% Ser:
9
50
42
42
0
9
0
0
0
0
0
0
0
0
42
% S
% Thr:
0
0
0
0
17
0
42
17
0
42
0
9
0
0
0
% T
% Val:
9
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
0
42
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _