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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLR2C
All Species:
37.58
Human Site:
S122
Identified Species:
63.59
UniProt:
P19387
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19387
NP_116558.1
275
31441
S122
V
T
S
R
D
L
I
S
N
S
P
R
V
I
P
Chimpanzee
Pan troglodytes
XP_510992
242
27800
V97
N
S
P
R
V
I
P
V
T
S
R
N
R
D
N
Rhesus Macaque
Macaca mulatta
XP_001098211
257
29446
T112
V
R
C
N
E
D
Q
T
R
H
V
T
S
R
D
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P97760
275
31292
S122
V
T
S
R
D
L
I
S
N
S
P
R
V
I
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511558
352
38872
S199
V
T
S
R
D
L
I
S
N
S
P
R
V
I
P
Chicken
Gallus gallus
XP_414001
275
31371
S122
V
T
S
R
D
L
I
S
N
N
P
R
V
I
P
Frog
Xenopus laevis
NP_001084998
275
31317
S122
V
T
S
R
D
L
V
S
N
N
L
R
V
I
P
Zebra Danio
Brachydanio rerio
NP_956215
275
31337
S122
V
T
S
R
D
L
L
S
N
N
P
R
V
I
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477419
275
31224
S122
V
T
T
A
D
L
K
S
S
N
A
K
V
L
P
Honey Bee
Apis mellifera
XP_624836
276
31595
S122
V
T
T
A
D
F
K
S
S
D
P
R
V
L
P
Nematode Worm
Caenorhab. elegans
NP_492361
282
32359
P122
V
T
T
E
H
L
M
P
M
H
N
L
D
T
T
Sea Urchin
Strong. purpuratus
XP_001176308
275
30823
S122
V
T
S
R
D
L
L
S
S
N
Q
K
V
V
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39211
319
35443
S127
V
T
S
R
D
L
Y
S
A
D
P
T
V
T
P
Baker's Yeast
Sacchar. cerevisiae
P16370
318
35279
I120
V
Y
S
K
D
L
V
I
V
S
N
L
M
G
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.8
77.8
N.A.
N.A.
96.7
N.A.
N.A.
69.5
96.3
93.8
89.8
N.A.
69
69.9
54.9
71.6
Protein Similarity:
100
86.9
81.4
N.A.
N.A.
97
N.A.
N.A.
74.7
99.6
98.1
96.7
N.A.
89
89.8
75.1
86.1
P-Site Identity:
100
13.3
6.6
N.A.
N.A.
100
N.A.
N.A.
100
93.3
80
86.6
N.A.
46.6
53.3
20
60
P-Site Similarity:
100
26.6
20
N.A.
N.A.
100
N.A.
N.A.
100
100
93.3
100
N.A.
80
73.3
33.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
40.4
40.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
57.3
57.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
66.6
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
15
0
0
0
0
8
0
8
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
79
8
0
0
0
15
0
0
8
8
8
% D
% Glu:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
8
0
0
0
0
15
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
29
8
0
0
0
0
0
43
0
% I
% Lys:
0
0
0
8
0
0
15
0
0
0
0
15
0
0
0
% K
% Leu:
0
0
0
0
0
79
15
0
0
0
8
15
0
15
0
% L
% Met:
0
0
0
0
0
0
8
0
8
0
0
0
8
0
0
% M
% Asn:
8
0
0
8
0
0
0
0
43
36
15
8
0
0
8
% N
% Pro:
0
0
8
0
0
0
8
8
0
0
50
0
0
0
72
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% Q
% Arg:
0
8
0
65
0
0
0
0
8
0
8
50
8
8
8
% R
% Ser:
0
8
65
0
0
0
0
72
22
36
0
0
8
0
0
% S
% Thr:
0
79
22
0
0
0
0
8
8
0
0
15
0
15
8
% T
% Val:
93
0
0
0
8
0
15
8
8
0
8
0
72
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _