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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLR2C
All Species:
35.15
Human Site:
S257
Identified Species:
59.49
UniProt:
P19387
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19387
NP_116558.1
275
31441
S257
S
G
L
K
K
K
L
S
D
L
Q
T
Q
L
S
Chimpanzee
Pan troglodytes
XP_510992
242
27800
D225
G
L
K
K
K
L
S
D
L
Q
T
Q
L
S
H
Rhesus Macaque
Macaca mulatta
XP_001098211
257
29446
S240
K
G
F
T
T
T
W
S
P
V
A
L
C
V
L
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P97760
275
31292
S257
S
G
L
K
K
K
L
S
D
L
Q
T
Q
L
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511558
352
38872
S334
S
G
L
K
K
K
L
S
D
L
Q
T
Q
L
S
Chicken
Gallus gallus
XP_414001
275
31371
S257
S
G
L
K
K
K
L
S
D
L
Q
T
Q
L
S
Frog
Xenopus laevis
NP_001084998
275
31317
S257
S
G
L
K
K
K
L
S
D
L
Q
T
Q
L
S
Zebra Danio
Brachydanio rerio
NP_956215
275
31337
S257
A
M
L
K
K
K
L
S
D
L
Q
T
Q
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477419
275
31224
S258
Q
V
L
K
N
K
L
S
N
L
Q
T
Q
L
S
Honey Bee
Apis mellifera
XP_624836
276
31595
S257
A
A
L
K
N
K
L
S
N
L
Q
T
Q
L
S
Nematode Worm
Caenorhab. elegans
NP_492361
282
32359
K263
G
I
G
I
L
K
R
K
L
E
E
L
N
M
A
Sea Urchin
Strong. purpuratus
XP_001176308
275
30823
S255
S
V
L
K
K
K
L
S
D
L
Q
T
Q
H
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39211
319
35443
P261
P
G
L
I
E
I
S
P
K
D
D
S
F
I
F
Baker's Yeast
Sacchar. cerevisiae
P16370
318
35279
L251
V
V
R
G
I
D
T
L
Q
K
K
V
A
S
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.8
77.8
N.A.
N.A.
96.7
N.A.
N.A.
69.5
96.3
93.8
89.8
N.A.
69
69.9
54.9
71.6
Protein Similarity:
100
86.9
81.4
N.A.
N.A.
97
N.A.
N.A.
74.7
99.6
98.1
96.7
N.A.
89
89.8
75.1
86.1
P-Site Identity:
100
13.3
13.3
N.A.
N.A.
100
N.A.
N.A.
100
100
100
86.6
N.A.
73.3
73.3
6.6
86.6
P-Site Similarity:
100
13.3
26.6
N.A.
N.A.
100
N.A.
N.A.
100
100
100
93.3
N.A.
80
86.6
26.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
40.4
40.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
57.3
57.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
8
0
0
0
0
0
0
0
0
8
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
0
0
8
0
8
50
8
8
0
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
8
8
0
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
8
% F
% Gly:
15
50
8
8
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% H
% Ile:
0
8
0
15
8
8
0
0
0
0
0
0
0
8
8
% I
% Lys:
8
0
8
72
58
72
0
8
8
8
8
0
0
0
0
% K
% Leu:
0
8
72
0
8
8
65
8
15
65
0
15
8
58
8
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
15
0
0
0
15
0
0
0
8
0
0
% N
% Pro:
8
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
8
8
65
8
65
0
0
% Q
% Arg:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% R
% Ser:
43
0
0
0
0
0
15
72
0
0
0
8
0
15
65
% S
% Thr:
0
0
0
8
8
8
8
0
0
0
8
65
0
0
0
% T
% Val:
8
22
0
0
0
0
0
0
0
8
0
8
0
8
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _