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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLR2E
All Species:
37.88
Human Site:
S49
Identified Species:
64.1
UniProt:
P19388
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19388
NP_002686.2
210
24551
S49
A
Q
S
G
D
K
P
S
E
G
R
P
R
R
T
Chimpanzee
Pan troglodytes
XP_512960
230
26508
S69
A
Q
F
G
D
K
P
S
E
G
R
P
R
R
T
Rhesus Macaque
Macaca mulatta
XP_001117242
278
31168
S49
A
Q
F
G
D
K
P
S
E
G
R
P
R
R
T
Dog
Lupus familis
XP_854641
208
24415
S49
A
Q
F
G
D
K
P
S
E
G
R
P
R
R
T
Cat
Felis silvestris
Mouse
Mus musculus
Q80UW8
210
24552
S49
A
Q
F
G
D
K
P
S
E
G
R
P
R
R
T
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418224
210
24625
S49
A
Q
F
G
D
K
P
S
E
G
R
P
R
R
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001003564
210
24630
S49
S
Q
F
G
D
K
P
S
E
G
R
P
R
R
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610630
210
24466
S49
E
M
F
G
D
K
P
S
E
K
R
P
A
R
S
Honey Bee
Apis mellifera
XP_396561
210
24561
S49
E
Q
F
G
D
K
P
S
E
K
R
P
A
R
S
Nematode Worm
Caenorhab. elegans
Q9N5K2
211
24330
S50
V
Q
Y
G
D
R
P
S
E
K
K
P
A
R
S
Sea Urchin
Strong. purpuratus
XP_783584
210
24575
S49
E
Q
F
G
D
K
P
S
E
N
R
P
S
R
K
Poplar Tree
Populus trichocarpa
XP_002331171
206
24432
K50
S
K
Y
G
N
N
M
K
R
E
D
L
V
I
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_188871
205
24283
K49
R
K
H
G
D
N
M
K
R
E
D
L
V
T
L
Baker's Yeast
Sacchar. cerevisiae
P20434
215
25061
G51
A
K
Y
C
D
S
M
G
R
P
Q
R
K
M
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.9
70.8
96.6
N.A.
98.5
N.A.
N.A.
N.A.
99
N.A.
94.2
N.A.
84.7
84.7
76.7
83.8
Protein Similarity:
100
87.8
73.7
97.1
N.A.
99.5
N.A.
N.A.
N.A.
99.5
N.A.
98.5
N.A.
90.4
92.3
88.6
91.4
P-Site Identity:
100
93.3
93.3
93.3
N.A.
93.3
N.A.
N.A.
N.A.
93.3
N.A.
80
N.A.
60
66.6
53.3
66.6
P-Site Similarity:
100
93.3
93.3
93.3
N.A.
93.3
N.A.
N.A.
N.A.
93.3
N.A.
86.6
N.A.
66.6
73.3
73.3
66.6
Percent
Protein Identity:
53.3
N.A.
N.A.
52.8
42.7
N.A.
Protein Similarity:
71.4
N.A.
N.A.
71.9
62.3
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
0
0
0
0
0
0
0
0
0
0
0
22
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
93
0
0
0
0
0
15
0
0
0
0
% D
% Glu:
22
0
0
0
0
0
0
0
79
15
0
0
0
0
0
% E
% Phe:
0
0
65
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
93
0
0
0
8
0
50
0
0
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
22
0
0
0
72
0
15
0
22
8
0
8
0
8
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
8
% L
% Met:
0
8
0
0
0
0
22
0
0
0
0
0
0
8
8
% M
% Asn:
0
0
0
0
8
15
0
0
0
8
0
0
0
0
15
% N
% Pro:
0
0
0
0
0
0
79
0
0
8
0
79
0
0
0
% P
% Gln:
0
72
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
8
0
0
0
0
8
0
0
22
0
72
8
50
79
0
% R
% Ser:
15
0
8
0
0
8
0
79
0
0
0
0
8
0
22
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
43
% T
% Val:
8
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
22
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _