KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLR2E
All Species:
40.3
Human Site:
Y90
Identified Species:
68.21
UniProt:
P19388
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19388
NP_002686.2
210
24551
Y90
G
I
K
T
I
K
V
Y
C
Q
R
M
Q
E
E
Chimpanzee
Pan troglodytes
XP_512960
230
26508
Y110
G
I
K
T
I
K
V
Y
C
Q
R
M
Q
E
E
Rhesus Macaque
Macaca mulatta
XP_001117242
278
31168
Y90
G
I
K
T
I
K
V
Y
C
Q
R
M
Q
E
E
Dog
Lupus familis
XP_854641
208
24415
Y90
G
I
K
T
I
K
V
Y
C
Q
R
M
Q
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q80UW8
210
24552
Y90
G
I
K
T
I
K
V
Y
C
Q
R
M
Q
E
E
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418224
210
24625
Y90
G
I
K
T
I
K
M
Y
C
Q
R
M
Q
E
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001003564
210
24630
Y90
G
I
K
T
I
K
M
Y
C
Q
R
M
Q
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610630
210
24466
Y90
G
I
K
T
I
K
T
Y
C
T
R
M
Q
E
E
Honey Bee
Apis mellifera
XP_396561
210
24561
Y90
G
I
K
T
I
K
T
Y
C
Q
R
M
Q
E
E
Nematode Worm
Caenorhab. elegans
Q9N5K2
211
24330
I91
G
I
K
T
I
K
A
I
C
Q
Q
M
Q
E
Q
Sea Urchin
Strong. purpuratus
XP_783584
210
24575
Y90
G
M
K
T
I
K
A
Y
C
Q
R
M
Q
E
E
Poplar Tree
Populus trichocarpa
XP_002331171
206
24432
R89
T
M
K
T
Y
T
N
R
M
K
S
E
N
V
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_188871
205
24283
R88
T
M
K
M
Y
T
N
R
M
K
S
E
N
V
F
Baker's Yeast
Sacchar. cerevisiae
P20434
215
25061
T95
V
G
V
K
T
M
K
T
F
V
I
H
I
Q
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.9
70.8
96.6
N.A.
98.5
N.A.
N.A.
N.A.
99
N.A.
94.2
N.A.
84.7
84.7
76.7
83.8
Protein Similarity:
100
87.8
73.7
97.1
N.A.
99.5
N.A.
N.A.
N.A.
99.5
N.A.
98.5
N.A.
90.4
92.3
88.6
91.4
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
93.3
N.A.
93.3
N.A.
86.6
93.3
73.3
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
100
N.A.
100
N.A.
86.6
93.3
86.6
93.3
Percent
Protein Identity:
53.3
N.A.
N.A.
52.8
42.7
N.A.
Protein Similarity:
71.4
N.A.
N.A.
71.9
62.3
N.A.
P-Site Identity:
13.3
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
15
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
79
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
15
0
79
79
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
15
% F
% Gly:
79
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
72
0
0
79
0
0
8
0
0
8
0
8
0
0
% I
% Lys:
0
0
93
8
0
79
8
0
0
15
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
22
0
8
0
8
15
0
15
0
0
79
0
0
0
% M
% Asn:
0
0
0
0
0
0
15
0
0
0
0
0
15
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
72
8
0
79
8
8
% Q
% Arg:
0
0
0
0
0
0
0
15
0
0
72
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
15
0
0
0
0
% S
% Thr:
15
0
0
86
8
15
15
8
0
8
0
0
0
0
0
% T
% Val:
8
0
8
0
0
0
36
0
0
8
0
0
0
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
15
0
0
72
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _