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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK2
All Species:
5.45
Human Site:
T537
Identified Species:
15
UniProt:
P19525
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19525
NP_001129123.1
551
62094
T537
S
E
I
L
R
T
L
T
V
W
K
K
S
P
E
Chimpanzee
Pan troglodytes
NP_001138509
552
62233
L537
T
S
E
I
L
R
T
L
T
V
W
K
K
S
P
Rhesus Macaque
Macaca mulatta
NP_001077417
554
62134
T541
S
E
I
L
S
T
L
T
T
W
K
K
S
P
E
Dog
Lupus familis
XP_854775
1113
124420
E1070
P
E
A
T
N
I
I
E
N
A
V
F
E
D
L
Cat
Felis silvestris
Mouse
Mus musculus
Q03963
515
58261
E502
E
I
L
K
T
L
A
E
W
R
N
I
S
E
K
Rat
Rattus norvegicus
Q63184
513
58240
A499
S
E
I
L
K
T
L
A
E
W
K
N
I
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989818
550
62328
L536
A
S
Q
I
I
D
I
L
K
S
R
D
K
D
N
Frog
Xenopus laevis
NP_001091256
578
65027
T561
P
K
R
R
P
K
A
T
Y
L
K
K
H
F
E
Zebra Danio
Brachydanio rerio
NP_001107942
682
77355
A659
R
P
E
D
R
P
D
A
T
D
L
I
L
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
80.5
21.1
N.A.
58.2
57.5
N.A.
N.A.
38.1
34.7
29.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.2
87.7
33.3
N.A.
71.3
70.7
N.A.
N.A.
56
55.1
45.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
86.6
6.6
N.A.
6.6
60
N.A.
N.A.
0
26.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
86.6
13.3
N.A.
20
66.6
N.A.
N.A.
26.6
33.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
12
0
0
0
23
23
0
12
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
12
0
12
12
0
0
12
0
12
0
34
0
% D
% Glu:
12
45
23
0
0
0
0
23
12
0
0
0
12
12
45
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
12
0
12
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% H
% Ile:
0
12
34
23
12
12
23
0
0
0
0
23
12
0
0
% I
% Lys:
0
12
0
12
12
12
0
0
12
0
45
45
23
0
12
% K
% Leu:
0
0
12
34
12
12
34
23
0
12
12
0
12
0
23
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
12
0
0
0
12
0
12
12
0
0
12
% N
% Pro:
23
12
0
0
12
12
0
0
0
0
0
0
0
23
12
% P
% Gln:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
12
0
12
12
23
12
0
0
0
12
12
0
0
0
0
% R
% Ser:
34
23
0
0
12
0
0
0
0
12
0
0
34
23
0
% S
% Thr:
12
0
0
12
12
34
12
34
34
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
12
12
12
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
12
34
12
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _