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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EN2
All Species:
27.27
Human Site:
S330
Identified Species:
50
UniProt:
P19622
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19622
NP_001418.2
333
34211
S330
T
T
A
K
E
G
K
S
D
S
E
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001146034
399
41238
S396
T
T
A
K
E
G
K
S
D
S
E
_
_
_
_
Rhesus Macaque
Macaca mulatta
XP_001106130
334
34311
S331
T
T
A
K
E
G
K
S
D
S
E
_
_
_
_
Dog
Lupus familis
XP_854121
247
25817
Cat
Felis silvestris
Mouse
Mus musculus
P09066
324
33799
S321
T
T
A
K
E
G
K
S
D
S
E
_
_
_
_
Rat
Rattus norvegicus
NP_001102684
323
33670
S320
T
T
A
K
E
G
K
S
D
S
E
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512614
188
20519
Chicken
Gallus gallus
Q05917
288
30431
S285
T
T
A
K
D
G
K
S
D
S
E
_
_
_
_
Frog
Xenopus laevis
P52729
265
29878
S262
T
T
S
K
D
G
K
S
D
S
E
_
_
_
_
Zebra Danio
Brachydanio rerio
P31533
261
29466
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02836
552
59392
E540
T
V
P
L
T
K
E
E
E
E
L
E
M
R
M
Honey Bee
Apis mellifera
P09076
109
12608
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794753
249
28228
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
73.1
98.1
46.2
N.A.
86.7
86.7
N.A.
48.9
66
57.3
56.1
N.A.
27.5
22.8
N.A.
38.7
Protein Similarity:
100
75.1
99
50.7
N.A.
87.9
88.5
N.A.
52.2
70.5
64.8
63.3
N.A.
37.3
27.3
N.A.
51.3
P-Site Identity:
100
100
100
0
N.A.
100
100
N.A.
0
90.9
81.8
0
N.A.
6.6
0
N.A.
0
P-Site Similarity:
100
100
100
0
N.A.
100
100
N.A.
0
100
100
0
N.A.
20
0
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
47
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
16
0
0
0
54
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
39
0
8
8
8
8
54
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
54
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
54
0
8
54
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
0
0
0
0
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
8
0
0
0
0
54
0
54
0
0
0
0
0
% S
% Thr:
62
54
0
0
8
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
54
54
54
54
% _