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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TBP All Species: 19.7
Human Site: Y139 Identified Species: 27.08
UniProt: P20226 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20226 NP_003185.1 339 37698 Y139 L P G T T P L Y P S P M T P M
Chimpanzee Pan troglodytes A6H907 376 41488 D176 S P E K P N S D S L S L A S I
Rhesus Macaque Macaca mulatta XP_001085250 288 31595 T99 V T P M T P I T P A T P A S E
Dog Lupus familis XP_854525 324 35731 Y124 L P G T T P L Y P S P M T P M
Cat Felis silvestris
Mouse Mus musculus P29037 316 34691 Y116 L P G T T P L Y P S P M T P M
Rat Rattus norvegicus A6H909 344 38336 N145 S S E T P N S N A L P V V L I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus O13270 302 33116 Y102 L P G T T P L Y P S P M T P M
Frog Xenopus laevis P27633 297 32684 S99 G N T P L Y P S P I T P M T P
Zebra Danio Brachydanio rerio Q7SXL3 302 33001 Y102 L P G N T P L Y T T P L T P M
Tiger Blowfish Takifugu rubipres Q6SJ94 322 35702 P123 G G G V H N S P F Y S M T P M
Fruit Fly Dros. melanogaster P20227 353 38433 I153 G G D A L S N I H Q T M G P S
Honey Bee Apis mellifera XP_623088 319 35720 P120 N T N H I A P P S I G P S T P
Nematode Worm Caenorhab. elegans P32085 340 36629 Q142 D R D A L T H Q A P A S N I A
Sea Urchin Strong. purpuratus P91809 265 29089 A77 P M A P L T P A T P A S S E S
Poplar Tree Populus trichocarpa
Maize Zea mays P50159 200 22277 V12 G L E G S Q P V D L S K H P S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P28148 200 22378 V12 G T E G S Q P V D L T K H P S
Baker's Yeast Sacchar. cerevisiae P13393 240 26985 E52 D I K R A A P E S E K D T S A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 56.1 84.6 93.5 N.A. 91.1 50.2 N.A. N.A. 87.9 81.4 80.8 58.7 58 61.6 52 59.5
Protein Similarity: 100 64 84.9 93.8 N.A. 91.4 63.6 N.A. N.A. 88.5 84.6 84 67.5 67.4 66.9 60.8 65.4
P-Site Identity: 100 6.6 20 100 N.A. 100 13.3 N.A. N.A. 100 6.6 73.3 33.3 13.3 0 0 0
P-Site Similarity: 100 20 40 100 N.A. 100 26.6 N.A. N.A. 100 6.6 86.6 33.3 13.3 6.6 0 6.6
Percent
Protein Identity: N.A. 48.3 N.A. 47.7 48.6 N.A.
Protein Similarity: N.A. 53.6 N.A. 52.5 57.5 N.A.
P-Site Identity: N.A. 6.6 N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. 13.3 N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 6 12 6 12 0 6 12 6 12 0 12 0 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 12 0 12 0 0 0 0 6 12 0 0 6 0 0 0 % D
% Glu: 0 0 24 0 0 0 0 6 0 6 0 0 0 6 6 % E
% Phe: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % F
% Gly: 30 12 36 12 0 0 0 0 0 0 6 0 6 0 0 % G
% His: 0 0 0 6 6 0 6 0 6 0 0 0 12 0 0 % H
% Ile: 0 6 0 0 6 0 6 6 0 12 0 0 0 6 12 % I
% Lys: 0 0 6 6 0 0 0 0 0 0 6 12 0 0 0 % K
% Leu: 30 6 0 0 24 0 30 0 0 24 0 12 0 6 0 % L
% Met: 0 6 0 6 0 0 0 0 0 0 0 36 6 0 36 % M
% Asn: 6 6 6 6 0 18 6 6 0 0 0 0 6 0 0 % N
% Pro: 6 36 6 12 12 36 36 12 36 12 36 18 0 53 12 % P
% Gln: 0 0 0 0 0 12 0 6 0 6 0 0 0 0 0 % Q
% Arg: 0 6 0 6 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 12 6 0 0 12 6 18 6 18 24 18 12 12 18 24 % S
% Thr: 0 18 6 30 36 12 0 6 12 6 24 0 42 12 0 % T
% Val: 6 0 0 6 0 0 0 12 0 0 0 6 6 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 6 0 30 0 6 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _