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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHRM3
All Species:
25.76
Human Site:
S291
Identified Species:
51.52
UniProt:
P20309
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20309
NP_000731.1
590
66128
S291
T
G
S
S
R
S
C
S
S
Y
E
L
Q
Q
Q
Chimpanzee
Pan troglodytes
Q9N2A4
590
65944
S291
T
G
S
S
R
S
C
S
S
Y
E
L
Q
Q
Q
Rhesus Macaque
Macaca mulatta
P56490
532
60122
C253
H
R
A
L
F
R
S
C
L
R
C
P
R
P
T
Dog
Lupus familis
XP_546069
652
72649
S353
T
G
S
S
R
S
C
S
S
Y
E
L
Q
Q
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERZ3
589
66194
S290
T
G
S
S
R
S
C
S
S
Y
E
L
Q
Q
Q
Rat
Rattus norvegicus
P08483
589
66047
S290
T
G
S
S
R
S
C
S
S
Y
E
L
Q
Q
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514553
584
63621
R293
A
P
P
W
G
R
T
R
T
P
R
R
K
A
G
Chicken
Gallus gallus
P49578
639
71958
S339
T
G
S
S
R
S
L
S
S
Y
E
L
Q
R
Q
Frog
Xenopus laevis
P30544
484
54107
Y206
G
T
A
I
A
A
F
Y
L
P
V
V
I
M
T
Zebra Danio
Brachydanio rerio
XP_700381
665
73838
S361
H
L
H
A
T
R
G
S
S
R
S
C
S
S
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P16395
805
86605
H327
D
E
N
T
V
V
N
H
A
S
G
G
L
L
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U7D5
611
69544
S288
S
T
Q
S
F
R
N
S
K
M
W
K
K
V
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
48.8
83.7
N.A.
91.5
91.5
N.A.
67.9
74.8
39.6
55.1
N.A.
34.1
N.A.
35.3
N.A.
Protein Similarity:
100
99.6
62.8
87.1
N.A.
95.7
95.4
N.A.
74.4
80.5
56.2
66.9
N.A.
48
N.A.
52.2
N.A.
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
0
86.6
0
13.3
N.A.
0
N.A.
13.3
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
13.3
93.3
20
20
N.A.
20
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
17
9
9
9
0
0
9
0
0
0
0
9
9
% A
% Cys:
0
0
0
0
0
0
42
9
0
0
9
9
0
0
0
% C
% Asp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
9
0
0
0
0
0
0
0
0
50
0
0
0
0
% E
% Phe:
0
0
0
0
17
0
9
0
0
0
0
0
0
0
9
% F
% Gly:
9
50
0
0
9
0
9
0
0
0
9
9
0
0
9
% G
% His:
17
0
9
0
0
0
0
9
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
9
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
9
0
0
9
17
0
9
% K
% Leu:
0
9
0
9
0
0
9
0
17
0
0
50
9
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
9
0
% M
% Asn:
0
0
9
0
0
0
17
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
9
0
0
0
0
0
0
17
0
9
0
9
0
% P
% Gln:
0
0
9
0
0
0
0
0
0
0
0
0
50
42
50
% Q
% Arg:
0
9
0
0
50
34
0
9
0
17
9
9
9
9
0
% R
% Ser:
9
0
50
59
0
50
9
67
59
9
9
0
9
9
0
% S
% Thr:
50
17
0
9
9
0
9
0
9
0
0
0
0
0
17
% T
% Val:
0
0
0
0
9
9
0
0
0
0
9
9
0
9
0
% V
% Trp:
0
0
0
9
0
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
0
50
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _