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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH3
All Species:
7.58
Human Site:
S186
Identified Species:
15.15
UniProt:
P20585
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20585
NP_002430.2
1137
127440
S186
N
A
V
S
S
E
D
S
K
R
Q
I
N
Q
K
Chimpanzee
Pan troglodytes
XP_526872
653
74467
Rhesus Macaque
Macaca mulatta
XP_001110439
1124
126700
S174
N
A
V
S
S
E
D
S
K
C
Q
I
K
Q
K
Dog
Lupus familis
XP_536307
1124
126796
S174
N
V
I
S
S
E
D
S
K
S
H
I
N
Q
K
Cat
Felis silvestris
Mouse
Mus musculus
P13705
1091
123056
A146
T
L
Q
R
A
K
N
A
V
L
S
E
D
S
K
Rat
Rattus norvegicus
XP_001065837
1105
124697
A146
T
L
Q
R
A
K
N
A
V
L
S
E
D
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512218
1058
119728
I155
T
N
K
R
T
K
S
I
Y
T
P
L
E
L
Q
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001103184
1083
121769
E147
M
H
N
E
M
V
E
E
F
K
E
E
P
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193092
988
109454
K107
P
R
S
P
V
G
S
K
S
E
T
I
Q
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O65607
1081
119348
I147
I
A
A
R
V
L
G
I
Y
A
H
M
D
H
N
Baker's Yeast
Sacchar. cerevisiae
P25336
1018
116515
D136
T
A
K
L
T
P
L
D
K
Q
V
K
D
L
K
Red Bread Mold
Neurospora crassa
Q7SD11
1145
125674
E161
A
A
V
E
G
E
G
E
E
G
E
D
D
E
E
Conservation
Percent
Protein Identity:
100
54.1
95.6
83.1
N.A.
78.3
78.8
N.A.
71.5
N.A.
N.A.
50.4
N.A.
N.A.
N.A.
N.A.
40.8
Protein Similarity:
100
56.1
96.6
88.7
N.A.
86
86.2
N.A.
81.2
N.A.
N.A.
68.5
N.A.
N.A.
N.A.
N.A.
57.4
P-Site Identity:
100
0
86.6
73.3
N.A.
6.6
6.6
N.A.
0
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
0
86.6
80
N.A.
40
40
N.A.
26.6
N.A.
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.6
30.4
36.7
Protein Similarity:
N.A.
N.A.
N.A.
55.8
49.5
55.9
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
20
P-Site Similarity:
N.A.
N.A.
N.A.
20
40
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
42
9
0
17
0
0
17
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
25
9
0
0
0
9
42
0
0
% D
% Glu:
0
0
0
17
0
34
9
17
9
9
17
25
9
9
17
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
9
9
17
0
0
9
0
0
0
0
0
% G
% His:
0
9
0
0
0
0
0
0
0
0
17
0
0
9
0
% H
% Ile:
9
0
9
0
0
0
0
17
0
0
0
34
0
9
0
% I
% Lys:
0
0
17
0
0
25
0
9
34
9
0
9
9
9
59
% K
% Leu:
0
17
0
9
0
9
9
0
0
17
0
9
0
17
0
% L
% Met:
9
0
0
0
9
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
25
9
9
0
0
0
17
0
0
0
0
0
17
0
9
% N
% Pro:
9
0
0
9
0
9
0
0
0
0
9
0
9
0
0
% P
% Gln:
0
0
17
0
0
0
0
0
0
9
17
0
9
25
9
% Q
% Arg:
0
9
0
34
0
0
0
0
0
9
0
0
0
0
0
% R
% Ser:
0
0
9
25
25
0
17
25
9
9
17
0
0
17
0
% S
% Thr:
34
0
0
0
17
0
0
0
0
9
9
0
0
0
0
% T
% Val:
0
9
25
0
17
9
0
0
17
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
17
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _