KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPR2
All Species:
26.36
Human Site:
Y681
Identified Species:
52.73
UniProt:
P20594
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20594
NP_003986.2
1047
117022
Y681
P
D
D
S
H
A
L
Y
A
K
K
L
W
T
A
Chimpanzee
Pan troglodytes
XP_001168194
1047
116964
Y681
P
D
D
S
H
A
L
Y
A
K
K
L
W
T
A
Rhesus Macaque
Macaca mulatta
XP_001085221
1047
116990
Y681
P
D
D
S
H
A
L
Y
A
K
K
L
W
T
A
Dog
Lupus familis
XP_531993
999
112273
K656
L
P
T
T
G
M
Q
K
A
D
V
Y
S
F
G
Cat
Felis silvestris
Mouse
Mus musculus
Q6VVW5
1047
117039
Y681
P
D
D
S
H
A
L
Y
A
K
K
L
W
T
A
Rat
Rattus norvegicus
P16067
1047
117109
Y681
P
D
D
S
H
A
L
Y
A
K
K
L
W
T
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517544
743
84256
K435
S
P
K
E
I
V
Q
K
V
R
H
G
Q
R
P
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084176
1082
122776
Y717
T
D
D
G
Y
A
L
Y
A
K
K
L
W
T
A
Zebra Danio
Brachydanio rerio
XP_689479
1088
124806
Y723
N
E
D
S
H
A
L
Y
A
K
K
L
W
T
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
E689
E
P
N
K
S
E
L
E
L
K
R
A
L
C
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
W721
P
P
K
K
R
L
L
W
V
A
P
E
V
L
R
Sea Urchin
Strong. purpuratus
P16065
1125
126238
H730
Q
D
V
D
L
G
D
H
A
K
L
A
R
Q
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
89.1
N.A.
98.5
98.5
N.A.
64.5
N.A.
72.2
58.1
N.A.
32.5
N.A.
28.7
36.2
Protein Similarity:
100
99.9
100
90
N.A.
99.4
99.3
N.A.
67
N.A.
82.9
69.7
N.A.
49
N.A.
46.7
52.2
P-Site Identity:
100
100
100
6.6
N.A.
100
100
N.A.
0
N.A.
80
86.6
N.A.
13.3
N.A.
13.3
20
P-Site Similarity:
100
100
100
13.3
N.A.
100
100
N.A.
6.6
N.A.
86.6
93.3
N.A.
26.6
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
59
0
0
75
9
0
17
0
0
59
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
59
59
9
0
0
9
0
0
9
0
0
0
0
0
% D
% Glu:
9
9
0
9
0
9
0
9
0
0
0
9
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
0
9
9
9
0
0
0
0
0
9
0
0
9
% G
% His:
0
0
0
0
50
0
0
9
0
0
9
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
17
17
0
0
0
17
0
75
59
0
0
0
0
% K
% Leu:
9
0
0
0
9
9
75
0
9
0
9
59
9
9
9
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
9
% M
% Asn:
9
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
50
34
0
0
0
0
0
0
0
0
9
0
0
0
9
% P
% Gln:
9
0
0
0
0
0
17
0
0
0
0
0
9
9
0
% Q
% Arg:
0
0
0
0
9
0
0
0
0
9
9
0
9
9
9
% R
% Ser:
9
0
0
50
9
0
0
0
0
0
0
0
9
0
0
% S
% Thr:
9
0
9
9
0
0
0
0
0
0
0
0
0
59
0
% T
% Val:
0
0
9
0
0
9
0
0
17
0
9
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
59
0
0
% W
% Tyr:
0
0
0
0
9
0
0
59
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _