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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: M6PR All Species: 20.3
Human Site: S86 Identified Species: 40.61
UniProt: P20645 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20645 NP_002346.1 277 30993 S86 R E A G N H T S G A G L V Q I
Chimpanzee Pan troglodytes XP_001137994 244 27171 C78 Y I Y I F R V C R E A G N H T
Rhesus Macaque Macaca mulatta XP_001113975 278 31085 S87 R E A G N H T S G A G L V Q I
Dog Lupus familis XP_534894 396 43228 S205 R E A G N R T S G A G L V Q I
Cat Felis silvestris
Mouse Mus musculus P24668 278 31154 S87 R E A S N H S S G A G L V Q I
Rat Rattus norvegicus Q6AY20 278 31077 S87 R E A G N H S S G A G L V Q I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514710 258 28364 A91 R E S E K E R A L L E K L A P
Chicken Gallus gallus XP_416477 298 33190 M93 D E S T E S Q M E K A L L K K
Frog Xenopus laevis NP_001080870 273 29899 D95 Q S K E G S T D T S V I G R I
Zebra Danio Brachydanio rerio NP_998370 265 29164 I89 Q E K G G K T I R I G D Y S K
Tiger Blowfish Takifugu rubipres NP_001033033 272 30118 T97 K K K E A K P T V I G T Y N L
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784873 183 20114 S17 R M E D M S T S S A L S E C S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.7 98.9 66.4 N.A. 91.7 91 N.A. 54.1 52 59.2 48.7 42.9 N.A. N.A. N.A. 30.3
Protein Similarity: 100 87.7 99.2 68.6 N.A. 95.6 95.6 N.A. 63.9 63.7 72.9 66.7 59.9 N.A. N.A. N.A. 42.6
P-Site Identity: 100 0 100 93.3 N.A. 86.6 93.3 N.A. 13.3 13.3 13.3 26.6 6.6 N.A. N.A. N.A. 26.6
P-Site Similarity: 100 0 100 93.3 N.A. 93.3 100 N.A. 33.3 33.3 40 33.3 33.3 N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 42 0 9 0 0 9 0 50 17 0 0 9 0 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 0 0 9 0 % C
% Asp: 9 0 0 9 0 0 0 9 0 0 0 9 0 0 0 % D
% Glu: 0 67 9 25 9 9 0 0 9 9 9 0 9 0 0 % E
% Phe: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 42 17 0 0 0 42 0 59 9 9 0 0 % G
% His: 0 0 0 0 0 34 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 9 0 9 0 0 0 9 0 17 0 9 0 0 50 % I
% Lys: 9 9 25 0 9 17 0 0 0 9 0 9 0 9 17 % K
% Leu: 0 0 0 0 0 0 0 0 9 9 9 50 17 0 9 % L
% Met: 0 9 0 0 9 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 42 0 0 0 0 0 0 0 9 9 0 % N
% Pro: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 9 % P
% Gln: 17 0 0 0 0 0 9 0 0 0 0 0 0 42 0 % Q
% Arg: 59 0 0 0 0 17 9 0 17 0 0 0 0 9 0 % R
% Ser: 0 9 17 9 0 25 17 50 9 9 0 9 0 9 9 % S
% Thr: 0 0 0 9 0 0 50 9 9 0 0 9 0 0 9 % T
% Val: 0 0 0 0 0 0 9 0 9 0 9 0 42 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 9 0 0 0 0 0 0 0 0 0 17 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _