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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: M6PR All Species: 6.06
Human Site: T27 Identified Species: 12.12
UniProt: P20645 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20645 NP_002346.1 277 30993 T27 A V R E S W Q T E E K T C D L
Chimpanzee Pan troglodytes XP_001137994 244 27171 V21 L L L L A V A V R E S W Q T E
Rhesus Macaque Macaca mulatta XP_001113975 278 31085 A28 A V R E S W Q A E E K T C D L
Dog Lupus familis XP_534894 396 43228 T146 A V R E S W Q T E E K T C D L
Cat Felis silvestris
Mouse Mus musculus P24668 278 31154 I28 A V R E S W Q I E E K S C D L
Rat Rattus norvegicus Q6AY20 278 31077 I28 A V R E S W Q I E E K S C D L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514710 258 28364 I30 A P R Q G W A I R R L R M V P
Chicken Gallus gallus XP_416477 298 33190 P27 A P A R R L R P V P E Q P S F
Frog Xenopus laevis NP_001080870 273 29899 S36 L V G G D K K S A T E Q A V L
Zebra Danio Brachydanio rerio NP_998370 265 29164 K28 R F N T S N C K L V S D S E S
Tiger Blowfish Takifugu rubipres NP_001033033 272 30118 N30 G G P V C A T N S T Q S C K L
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784873 183 20114
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.7 98.9 66.4 N.A. 91.7 91 N.A. 54.1 52 59.2 48.7 42.9 N.A. N.A. N.A. 30.3
Protein Similarity: 100 87.7 99.2 68.6 N.A. 95.6 95.6 N.A. 63.9 63.7 72.9 66.7 59.9 N.A. N.A. N.A. 42.6
P-Site Identity: 100 6.6 93.3 100 N.A. 86.6 86.6 N.A. 20 6.6 13.3 6.6 13.3 N.A. N.A. N.A. 0
P-Site Similarity: 100 20 93.3 100 N.A. 93.3 93.3 N.A. 26.6 20 33.3 13.3 26.6 N.A. N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 59 0 9 0 9 9 17 9 9 0 0 0 9 0 0 % A
% Cys: 0 0 0 0 9 0 9 0 0 0 0 0 50 0 0 % C
% Asp: 0 0 0 0 9 0 0 0 0 0 0 9 0 42 0 % D
% Glu: 0 0 0 42 0 0 0 0 42 50 17 0 0 9 9 % E
% Phe: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 9 % F
% Gly: 9 9 9 9 9 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 9 9 9 0 0 42 0 0 9 0 % K
% Leu: 17 9 9 9 0 9 0 0 9 0 9 0 0 0 59 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % M
% Asn: 0 0 9 0 0 9 0 9 0 0 0 0 0 0 0 % N
% Pro: 0 17 9 0 0 0 0 9 0 9 0 0 9 0 9 % P
% Gln: 0 0 0 9 0 0 42 0 0 0 9 17 9 0 0 % Q
% Arg: 9 0 50 9 9 0 9 0 17 9 0 9 0 0 0 % R
% Ser: 0 0 0 0 50 0 0 9 9 0 17 25 9 9 9 % S
% Thr: 0 0 0 9 0 0 9 17 0 17 0 25 0 9 0 % T
% Val: 0 50 0 9 0 9 0 9 9 9 0 0 0 17 0 % V
% Trp: 0 0 0 0 0 50 0 0 0 0 0 9 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _