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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAK All Species: 13.03
Human Site: S294 Identified Species: 23.89
UniProt: P20794 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20794 NP_005897.1 623 70581 S294 G Q V L G P S S N H L E S K Q
Chimpanzee Pan troglodytes XP_001167620 623 70608 S294 G Q V L G P S S N H L E S K Q
Rhesus Macaque Macaca mulatta XP_001088297 623 70579 S294 G Q V L G P S S N H L E S K Q
Dog Lupus familis XP_535886 623 70299 S294 G Q V L G P S S H H P E L K Q
Cat Felis silvestris
Mouse Mus musculus Q04859 622 70031 A294 G Q V L G S S A H H L D T K Q
Rat Rattus norvegicus P20793 622 69906 A294 G Q V L G P S A H H L D A K Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514363 623 70669 P294 G Q I V G S P P Q Y M E K K Q
Chicken Gallus gallus XP_418948 628 70589 P294 G Q V L G P P P Q Y L E K Q T
Frog Xenopus laevis P23437 297 33852
Zebra Danio Brachydanio rerio NP_956240 633 71283 P295 G Q L L G P R P M T P D V R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392924 569 65790 I250 R T S L S V L I P N A G Q E A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001200813 576 64528 E256 I I P N A S P E S I H L I R D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43294 443 50877 M124 M L Q G L A H M H K N G Y F H
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97.7 91.4 N.A. 84.1 85 N.A. 76.2 71.9 21.8 59.8 N.A. N.A. 46.2 N.A. 49.4
Protein Similarity: 100 99.5 99.3 93.7 N.A. 90.3 91.1 N.A. 85.5 81.5 33 71.8 N.A. N.A. 60.5 N.A. 64.3
P-Site Identity: 100 100 100 80 N.A. 66.6 73.3 N.A. 40 53.3 0 33.3 N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 100 N.A. 66.6 66.6 0 60 N.A. N.A. 20 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 34.8 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 50.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 8 0 16 0 0 8 0 8 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 24 0 0 8 % D
% Glu: 0 0 0 0 0 0 0 8 0 0 0 47 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 70 0 0 8 70 0 0 0 0 0 0 16 0 0 0 % G
% His: 0 0 0 0 0 0 8 0 31 47 8 0 0 0 8 % H
% Ile: 8 8 8 0 0 0 0 8 0 8 0 0 8 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 8 0 0 16 54 8 % K
% Leu: 0 8 8 70 8 0 8 0 0 0 47 8 8 0 0 % L
% Met: 8 0 0 0 0 0 0 8 8 0 8 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 24 8 8 0 0 0 0 % N
% Pro: 0 0 8 0 0 54 24 24 8 0 16 0 0 0 0 % P
% Gln: 0 70 8 0 0 0 0 0 16 0 0 0 8 8 54 % Q
% Arg: 8 0 0 0 0 0 8 0 0 0 0 0 0 16 0 % R
% Ser: 0 0 8 0 8 24 47 31 8 0 0 0 24 0 0 % S
% Thr: 0 8 0 0 0 0 0 0 0 8 0 0 8 0 8 % T
% Val: 0 0 54 8 0 8 0 0 0 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 16 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _