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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAK All Species: 20.61
Human Site: S420 Identified Species: 37.78
UniProt: P20794 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20794 NP_005897.1 623 70581 S420 Y D F G A S H S K K P S M G V
Chimpanzee Pan troglodytes XP_001167620 623 70608 S420 Y D F G A S H S K K P S M G V
Rhesus Macaque Macaca mulatta XP_001088297 623 70579 S420 Y D F G A S H S K K P S M G V
Dog Lupus familis XP_535886 623 70299 S420 C D L G A S H S K K P S M G V
Cat Felis silvestris
Mouse Mus musculus Q04859 622 70031 S419 D D L G A S H S K K P S M E A
Rat Rattus norvegicus P20793 622 69906 H419 D C D L G A S H S K K P S M D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514363 623 70669 S419 S D L G A V H S K K P S M S V
Chicken Gallus gallus XP_418948 628 70589 G425 E L D D A E F G M S C S K K P
Frog Xenopus laevis P23437 297 33852 N95 K K F M D G S N I S G I S L A
Zebra Danio Brachydanio rerio NP_956240 633 71283 S429 Q K P L Y T F S T V T K L P N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392924 569 65790 D367 Q S N P Q K L D E D D F A E L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001200813 576 64528 N373 P V Q E K A P N A G N K S G R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43294 443 50877 M241 A K S I S R I M S I S H T E F
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97.7 91.4 N.A. 84.1 85 N.A. 76.2 71.9 21.8 59.8 N.A. N.A. 46.2 N.A. 49.4
Protein Similarity: 100 99.5 99.3 93.7 N.A. 90.3 91.1 N.A. 85.5 81.5 33 71.8 N.A. N.A. 60.5 N.A. 64.3
P-Site Identity: 100 100 100 86.6 N.A. 73.3 6.6 N.A. 73.3 13.3 6.6 6.6 N.A. N.A. 0 N.A. 6.6
P-Site Similarity: 100 100 100 86.6 N.A. 73.3 13.3 N.A. 73.3 13.3 13.3 20 N.A. N.A. 13.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 34.8 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 50.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 54 16 0 0 8 0 0 0 8 0 16 % A
% Cys: 8 8 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 16 47 16 8 8 0 0 8 0 8 8 0 0 0 8 % D
% Glu: 8 0 0 8 0 8 0 0 8 0 0 0 0 24 0 % E
% Phe: 0 0 31 0 0 0 16 0 0 0 0 8 0 0 8 % F
% Gly: 0 0 0 47 8 8 0 8 0 8 8 0 0 39 0 % G
% His: 0 0 0 0 0 0 47 8 0 0 0 8 0 0 0 % H
% Ile: 0 0 0 8 0 0 8 0 8 8 0 8 0 0 0 % I
% Lys: 8 24 0 0 8 8 0 0 47 54 8 16 8 8 0 % K
% Leu: 0 8 24 16 0 0 8 0 0 0 0 0 8 8 8 % L
% Met: 0 0 0 8 0 0 0 8 8 0 0 0 47 8 0 % M
% Asn: 0 0 8 0 0 0 0 16 0 0 8 0 0 0 8 % N
% Pro: 8 0 8 8 0 0 8 0 0 0 47 8 0 8 8 % P
% Gln: 16 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % R
% Ser: 8 8 8 0 8 39 16 54 16 16 8 54 24 8 0 % S
% Thr: 0 0 0 0 0 8 0 0 8 0 8 0 8 0 0 % T
% Val: 0 8 0 0 0 8 0 0 0 8 0 0 0 0 39 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 24 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _