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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAK All Species: 11.82
Human Site: T339 Identified Species: 21.67
UniProt: P20794 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20794 NP_005897.1 623 70581 T339 V G Q P Q P K T S Q Q P L Q P
Chimpanzee Pan troglodytes XP_001167620 623 70608 T339 V G Q P Q P K T S Q Q P L Q P
Rhesus Macaque Macaca mulatta XP_001088297 623 70579 T339 V G Q P Q P K T S Q Q P L Q P
Dog Lupus familis XP_535886 623 70299 N339 V R Q P Q P K N S H Q P L Q S
Cat Felis silvestris
Mouse Mus musculus Q04859 622 70031 K338 P A G Q P Q P K Q G H Q P L Q
Rat Rattus norvegicus P20793 622 69906 K338 P A G Q P Q P K Q G H Q P L Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514363 623 70669 R338 N Q L Q A Q S R L N H Q P L Q
Chicken Gallus gallus XP_418948 628 70589 A344 Q P Q P L S K A N H Q P L Q Q
Frog Xenopus laevis P23437 297 33852 T14 V E K I G E G T Y G V V Y K A
Zebra Danio Brachydanio rerio NP_956240 633 71283 S348 Q Q I P L P Q S L T Q T D T V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392924 569 65790 L286 L R Y P Y F Q L N V P R V I N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001200813 576 64528 A292 Q V G Q N L G A K A Q P P A Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43294 443 50877 M160 L A R E V A S M P P Y T E Y V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97.7 91.4 N.A. 84.1 85 N.A. 76.2 71.9 21.8 59.8 N.A. N.A. 46.2 N.A. 49.4
Protein Similarity: 100 99.5 99.3 93.7 N.A. 90.3 91.1 N.A. 85.5 81.5 33 71.8 N.A. N.A. 60.5 N.A. 64.3
P-Site Identity: 100 100 100 73.3 N.A. 0 0 N.A. 0 46.6 13.3 20 N.A. N.A. 6.6 N.A. 13.3
P-Site Similarity: 100 100 100 73.3 N.A. 0 0 N.A. 0 53.3 26.6 33.3 N.A. N.A. 33.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 34.8 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 50.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 24 0 0 8 8 0 16 0 8 0 0 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % D
% Glu: 0 8 0 8 0 8 0 0 0 0 0 0 8 0 0 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 24 24 0 8 0 16 0 0 24 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 16 24 0 0 0 0 % H
% Ile: 0 0 8 8 0 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 0 0 8 0 0 0 39 16 8 0 0 0 0 8 0 % K
% Leu: 16 0 8 0 16 8 0 8 16 0 0 0 39 24 0 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 8 0 0 8 16 8 0 0 0 0 8 % N
% Pro: 16 8 0 54 16 39 16 0 8 8 8 47 31 0 24 % P
% Gln: 24 16 39 31 31 24 16 0 16 24 54 24 0 39 39 % Q
% Arg: 0 16 8 0 0 0 0 8 0 0 0 8 0 0 0 % R
% Ser: 0 0 0 0 0 8 16 8 31 0 0 0 0 0 8 % S
% Thr: 0 0 0 0 0 0 0 31 0 8 0 16 0 8 0 % T
% Val: 39 8 0 0 8 0 0 0 0 8 8 8 8 0 16 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 8 0 0 0 8 0 8 0 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _