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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAK All Species: 10.61
Human Site: T386 Identified Species: 19.44
UniProt: P20794 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20794 NP_005897.1 623 70581 T386 M P T K P N G T L S H K S G R
Chimpanzee Pan troglodytes XP_001167620 623 70608 T386 M P T K P N G T L S H K S G R
Rhesus Macaque Macaca mulatta XP_001088297 623 70579 T386 V P T K P N G T L S H K S G R
Dog Lupus familis XP_535886 623 70299 A386 M P T K P N G A L G H K S A R
Cat Felis silvestris
Mouse Mus musculus Q04859 622 70031 S385 T I P V N S V S A L G H K G A
Rat Rattus norvegicus P20793 622 69906 S385 T I P T N P V S T V G H K G A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514363 623 70669 A385 P S P K Q N G A V G Y K N G R
Chicken Gallus gallus XP_418948 628 70589 P391 G K Q V A A G P Q N G T V G P
Frog Xenopus laevis P23437 297 33852 P61 L L K E L N H P N I V K L L D
Zebra Danio Brachydanio rerio NP_956240 633 71283 C395 D S W D D S D C S D T A A S L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392924 569 65790 R333 Q D G L M G S R A Q E K M I Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001200813 576 64528 R339 L S K V Q P K R D N A Q P K D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43294 443 50877 F207 L Y A L T P L F P G E S E I D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97.7 91.4 N.A. 84.1 85 N.A. 76.2 71.9 21.8 59.8 N.A. N.A. 46.2 N.A. 49.4
Protein Similarity: 100 99.5 99.3 93.7 N.A. 90.3 91.1 N.A. 85.5 81.5 33 71.8 N.A. N.A. 60.5 N.A. 64.3
P-Site Identity: 100 100 93.3 80 N.A. 6.6 6.6 N.A. 40 13.3 13.3 0 N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 100 100 100 80 N.A. 20 13.3 N.A. 60 20 26.6 13.3 N.A. N.A. 13.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 34.8 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 50.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 8 8 0 16 16 0 8 8 8 8 16 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 8 8 0 8 8 0 8 0 8 8 0 0 0 0 24 % D
% Glu: 0 0 0 8 0 0 0 0 0 0 16 0 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 8 0 8 0 0 8 47 0 0 24 24 0 0 54 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 31 16 0 0 0 % H
% Ile: 0 16 0 0 0 0 0 0 0 8 0 0 0 16 0 % I
% Lys: 0 8 16 39 0 0 8 0 0 0 0 54 16 8 0 % K
% Leu: 24 8 0 16 8 0 8 0 31 8 0 0 8 8 8 % L
% Met: 24 0 0 0 8 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 0 0 16 47 0 0 8 16 0 0 8 0 0 % N
% Pro: 8 31 24 0 31 24 0 16 8 0 0 0 8 0 8 % P
% Gln: 8 0 8 0 16 0 0 0 8 8 0 8 0 0 8 % Q
% Arg: 0 0 0 0 0 0 0 16 0 0 0 0 0 0 39 % R
% Ser: 0 24 0 0 0 16 8 16 8 24 0 8 31 8 0 % S
% Thr: 16 0 31 8 8 0 0 24 8 0 8 8 0 0 0 % T
% Val: 8 0 0 24 0 0 16 0 8 8 8 0 8 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 0 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _