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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CAST All Species: 25.76
Human Site: Y339 Identified Species: 62.96
UniProt: P20810 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P20810 NP_775086.1 708 76573 Y339 D E T I P S E Y R L K P A T D
Chimpanzee Pan troglodytes XP_518168 988 106575 Y619 D E T I P S E Y R L K P A M D
Rhesus Macaque Macaca mulatta XP_001091928 847 91183 Y473 D E T I P S E Y R L K P A T D
Dog Lupus familis XP_848621 747 79896 Y373 E E T V P S E Y R L K P A T D
Cat Felis silvestris
Mouse Mus musculus P51125 788 84903 Y419 E D T V P A E Y R L K P A K D
Rat Rattus norvegicus P27321 713 77294 E369 Q E K C G E D E D T V P A E Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512320 853 89249 H449 D D T V P P E H K L Q P A T D
Chicken Gallus gallus NP_001131122 768 81427 Y382 D D T I P P E Y R L T P E L D
Frog Xenopus laevis NP_001081910 931 96808 Y559 D D S I P P A Y R H L L D G K
Zebra Danio Brachydanio rerio NP_001124063 818 85259 Y395 D D T L P P Q Y R F K E E D L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 64.7 79 69.7 N.A. 61 64 N.A. 49.4 44 32.8 26.6 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 67.8 79.9 78 N.A. 70.8 74.7 N.A. 60.9 60 44.6 40.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 100 86.6 N.A. 66.6 20 N.A. 60 66.6 33.3 40 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 93.3 100 100 N.A. 93.3 26.6 N.A. 93.3 73.3 46.6 60 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 10 0 0 0 0 0 70 0 0 % A
% Cys: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 70 50 0 0 0 0 10 0 10 0 0 0 10 10 70 % D
% Glu: 20 50 0 0 0 10 70 10 0 0 0 10 20 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % F
% Gly: 0 0 0 0 10 0 0 0 0 0 0 0 0 10 0 % G
% His: 0 0 0 0 0 0 0 10 0 10 0 0 0 0 0 % H
% Ile: 0 0 0 50 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 10 0 0 0 0 0 10 0 60 0 0 10 10 % K
% Leu: 0 0 0 10 0 0 0 0 0 70 10 10 0 10 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 90 40 0 0 0 0 0 80 0 0 0 % P
% Gln: 10 0 0 0 0 0 10 0 0 0 10 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 80 0 0 0 0 0 0 % R
% Ser: 0 0 10 0 0 40 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 80 0 0 0 0 0 0 10 10 0 0 40 0 % T
% Val: 0 0 0 30 0 0 0 0 0 0 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 80 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _