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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HNF1A
All Species:
6.06
Human Site:
S550
Identified Species:
14.81
UniProt:
P20823
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20823
NP_000536.5
631
67356
S550
F
T
S
D
T
E
A
S
S
E
S
G
L
H
T
Chimpanzee
Pan troglodytes
XP_001148554
318
34959
A239
L
V
E
E
C
N
R
A
E
C
I
Q
R
G
V
Rhesus Macaque
Macaca mulatta
XP_001112182
533
58284
L454
P
V
Q
F
S
Q
Q
L
H
S
P
H
Q
Q
P
Dog
Lupus familis
XP_543429
631
67329
S550
F
T
S
D
A
E
A
S
S
E
S
G
L
H
T
Cat
Felis silvestris
Mouse
Mus musculus
P22361
628
67219
S549
T
S
D
T
E
A
S
S
E
P
G
L
H
E
P
Rat
Rattus norvegicus
P15257
628
67195
S549
T
S
D
T
E
A
S
S
E
P
G
L
H
E
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509401
497
55478
L418
V
Q
F
P
Q
Q
Q
L
H
S
P
H
Q
Q
P
Chicken
Gallus gallus
Q90867
634
69171
H554
F
T
S
D
S
E
T
H
T
D
S
G
I
H
T
Frog
Xenopus laevis
Q05041
605
66559
V526
S
L
T
P
S
K
Q
V
V
P
L
H
T
T
A
Zebra Danio
Brachydanio rerio
A1L1N5
559
61320
Q480
L
A
A
L
Q
P
V
Q
F
S
Q
Q
L
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
50.4
52.1
96.6
N.A.
94.6
94.4
N.A.
24.2
77.7
65.7
50.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
50.4
61.8
97.6
N.A.
95.8
96
N.A.
36.7
83.5
76.6
61.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
0
93.3
N.A.
6.6
6.6
N.A.
0
60
0
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
13.3
93.3
N.A.
20
20
N.A.
6.6
86.6
20
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
0
10
20
20
10
0
0
0
0
0
0
10
% A
% Cys:
0
0
0
0
10
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
0
20
30
0
0
0
0
0
10
0
0
0
0
0
% D
% Glu:
0
0
10
10
20
30
0
0
30
20
0
0
0
20
0
% E
% Phe:
30
0
10
10
0
0
0
0
10
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
20
30
0
10
0
% G
% His:
0
0
0
0
0
0
0
10
20
0
0
30
20
30
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% I
% Lys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% K
% Leu:
20
10
0
10
0
0
0
20
0
0
10
20
30
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
0
0
10
0
% N
% Pro:
10
0
0
20
0
10
0
0
0
30
20
0
0
0
40
% P
% Gln:
0
10
10
0
20
20
30
10
0
0
10
20
20
20
0
% Q
% Arg:
0
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% R
% Ser:
10
20
30
0
30
0
20
40
20
30
30
0
0
0
10
% S
% Thr:
20
30
10
20
10
0
10
0
10
0
0
0
10
10
30
% T
% Val:
10
20
0
0
0
0
10
10
10
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _