KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IMPDH1
All Species:
17.88
Human Site:
S176
Identified Species:
32.78
UniProt:
P20839
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20839
NP_001096075.1
514
55406
S176
K
D
H
T
T
L
L
S
E
V
M
T
P
R
I
Chimpanzee
Pan troglodytes
XP_516452
608
66107
E246
E
E
H
D
C
F
L
E
E
I
M
T
K
R
E
Rhesus Macaque
Macaca mulatta
XP_001089341
530
57059
S192
K
D
H
T
T
L
L
S
E
V
M
T
P
R
I
Dog
Lupus familis
XP_850999
611
65030
S273
K
D
H
T
T
L
L
S
E
V
M
T
P
R
N
Cat
Felis silvestris
Mouse
Mus musculus
P50096
514
55276
S176
K
D
H
T
T
L
L
S
E
V
M
T
P
R
V
Rat
Rattus norvegicus
NP_001102089
548
58591
K210
A
T
G
T
M
G
S
K
L
V
M
T
P
R
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509219
535
57111
A212
F
L
A
E
K
D
H
A
T
Y
L
S
E
V
M
Chicken
Gallus gallus
NP_001025772
514
55540
G176
S
E
H
D
L
P
L
G
E
I
M
T
K
R
E
Frog
Xenopus laevis
NP_001080792
514
55674
S176
K
D
Y
S
T
Y
L
S
E
V
M
T
K
R
E
Zebra Danio
Brachydanio rerio
NP_001014391
514
55622
E176
K
D
N
N
K
Y
L
E
E
A
M
T
K
R
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07152
537
57811
D198
Q
P
E
V
L
L
A
D
I
M
T
T
E
L
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SA34
502
54033
Y163
D
Q
K
E
V
K
I
Y
D
Y
M
K
S
C
E
Baker's Yeast
Sacchar. cerevisiae
P50094
524
56375
V184
D
S
L
V
V
S
E
V
M
T
K
N
P
V
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.2
92.4
80.6
N.A.
97.2
87.9
N.A.
85.2
83.6
92
90.6
N.A.
66.1
N.A.
N.A.
N.A.
Protein Similarity:
100
77.6
92.8
82
N.A.
98.8
88.8
N.A.
87
92
96.5
96.3
N.A.
80.4
N.A.
N.A.
N.A.
P-Site Identity:
100
40
100
93.3
N.A.
93.3
46.6
N.A.
0
40
66.6
46.6
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
60
100
93.3
N.A.
100
46.6
N.A.
26.6
53.3
80
53.3
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.6
61.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
64.7
77.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
0
8
8
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
16
47
0
16
0
8
0
8
8
0
0
0
0
0
0
% D
% Glu:
8
16
8
16
0
0
8
16
62
0
0
0
16
0
39
% E
% Phe:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
8
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
47
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
8
16
0
0
0
0
24
% I
% Lys:
47
0
8
0
16
8
0
8
0
0
8
8
31
0
0
% K
% Leu:
0
8
8
0
16
39
62
0
8
0
8
0
0
8
0
% L
% Met:
0
0
0
0
8
0
0
0
8
8
77
0
0
0
8
% M
% Asn:
0
0
8
8
0
0
0
0
0
0
0
8
0
0
8
% N
% Pro:
0
8
0
0
0
8
0
0
0
0
0
0
47
0
0
% P
% Gln:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
70
0
% R
% Ser:
8
8
0
8
0
8
8
39
0
0
0
8
8
0
0
% S
% Thr:
0
8
0
39
39
0
0
0
8
8
8
77
0
0
8
% T
% Val:
0
0
0
16
16
0
0
8
0
47
0
0
0
16
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
16
0
8
0
16
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _