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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK11B All Species: 38.79
Human Site: S616 Identified Species: 71.11
UniProt: P21127 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P21127 NP_277021.1 795 92707 S616 L L G A K E Y S T A V D M W S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001096162 526 59263 T348 L G A K E Y S T A V D M W S V
Dog Lupus familis XP_857026 795 92229 S616 L L G A K E Y S T A V D M W S
Cat Felis silvestris
Mouse Mus musculus P24788 784 91495 S605 L L G A K E Y S T A V D M W S
Rat Rattus norvegicus P46892 436 49529 T258 L G A K E Y S T A C D M W S V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026042 772 90216 S593 L L G A K E Y S T A I D M W S
Frog Xenopus laevis NP_001086696 788 91927 S609 L L G A K E Y S T A I D M W S
Zebra Danio Brachydanio rerio NP_001008646 800 92940 S621 L L G A K E Y S T A V D M W S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VPC0 952 108820 S739 L L C S P V Y S T P I D V W S
Honey Bee Apis mellifera XP_625138 840 98674 S657 L L N G K E Y S T P I D M W S
Nematode Worm Caenorhab. elegans Q09437 719 83549 S538 L L G T R L Y S T P V D M W S
Sea Urchin Strong. purpuratus XP_001192015 918 106921 S740 L L G T K V Y S T P I D M W S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P00546 298 34043 L120 V K K F M M Q L C K G I A Y C
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 65.6 94.7 N.A. 95.2 50.1 N.A. N.A. 89.8 84.7 77.3 N.A. 41.2 46.4 38.2 47
Protein Similarity: 100 N.A. 66 96.4 N.A. 97.2 52.7 N.A. N.A. 92.9 91.5 86.2 N.A. 54.7 60.2 55.3 61.4
P-Site Identity: 100 N.A. 6.6 100 N.A. 100 6.6 N.A. N.A. 93.3 93.3 100 N.A. 53.3 73.3 73.3 73.3
P-Site Similarity: 100 N.A. 20 100 N.A. 100 20 N.A. N.A. 100 100 100 N.A. 73.3 80 80 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 28.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 16 47 0 0 0 0 16 47 0 0 8 0 0 % A
% Cys: 0 0 8 0 0 0 0 0 8 8 0 0 0 0 8 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 16 77 0 0 0 % D
% Glu: 0 0 0 0 16 54 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 16 62 8 0 0 0 0 0 0 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 39 8 0 0 0 % I
% Lys: 0 8 8 16 62 0 0 0 0 8 0 0 0 0 0 % K
% Leu: 93 77 0 0 0 8 0 8 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 8 8 0 0 0 0 0 16 70 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 0 0 0 0 31 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 8 0 0 16 77 0 0 0 0 0 16 77 % S
% Thr: 0 0 0 16 0 0 0 16 77 0 0 0 0 0 0 % T
% Val: 8 0 0 0 0 16 0 0 0 8 39 0 8 0 16 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 16 77 0 % W
% Tyr: 0 0 0 0 0 16 77 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _