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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK11B All Species: 39.39
Human Site: Y518 Identified Species: 72.22
UniProt: P21127 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P21127 NP_277021.1 795 92707 Y518 K I Y I V M N Y V E H D L K S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001096162 526 59263 T260 D L K S L M E T M K Q P F L P
Dog Lupus familis XP_857026 795 92229 Y518 K I Y I V M N Y V E H D L K S
Cat Felis silvestris
Mouse Mus musculus P24788 784 91495 Y507 K I Y I V M N Y V E H D L K S
Rat Rattus norvegicus P46892 436 49529 T170 D L K S L M E T M K Q P F L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026042 772 90216 Y495 K I Y I V M N Y V E H D L K S
Frog Xenopus laevis NP_001086696 788 91927 Y511 K I Y I V M N Y V E H D L K S
Zebra Danio Brachydanio rerio NP_001008646 800 92940 Y523 K I Y I V M N Y V E H D L K S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VPC0 952 108820 Y638 K I F I V M D Y V E H D L K S
Honey Bee Apis mellifera XP_625138 840 98674 Y556 K I F I V M D Y V E H D L K S
Nematode Worm Caenorhab. elegans Q09437 719 83549 F437 K I Y M A M E F V E H D M K S
Sea Urchin Strong. purpuratus XP_001192015 918 106921 Y642 K I Y I V M D Y V E H D L K S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P00546 298 34043 Q32 A L D L R P G Q G Q R V V A L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 65.6 94.7 N.A. 95.2 50.1 N.A. N.A. 89.8 84.7 77.3 N.A. 41.2 46.4 38.2 47
Protein Similarity: 100 N.A. 66 96.4 N.A. 97.2 52.7 N.A. N.A. 92.9 91.5 86.2 N.A. 54.7 60.2 55.3 61.4
P-Site Identity: 100 N.A. 6.6 100 N.A. 100 6.6 N.A. N.A. 100 100 100 N.A. 86.6 86.6 66.6 93.3
P-Site Similarity: 100 N.A. 33.3 100 N.A. 100 33.3 N.A. N.A. 100 100 100 N.A. 100 100 86.6 100
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 28.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 0 8 0 0 0 24 0 0 0 0 77 0 0 0 % D
% Glu: 0 0 0 0 0 0 24 0 0 77 0 0 0 0 0 % E
% Phe: 0 0 16 0 0 0 0 8 0 0 0 0 16 0 0 % F
% Gly: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 77 0 0 0 0 % H
% Ile: 0 77 0 70 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 77 0 16 0 0 0 0 0 0 16 0 0 0 77 0 % K
% Leu: 0 24 0 8 16 0 0 0 0 0 0 0 70 16 8 % L
% Met: 0 0 0 8 0 93 0 0 16 0 0 0 8 0 0 % M
% Asn: 0 0 0 0 0 0 47 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 8 0 0 0 0 0 16 0 0 16 % P
% Gln: 0 0 0 0 0 0 0 8 0 8 16 0 0 0 0 % Q
% Arg: 0 0 0 0 8 0 0 0 0 0 8 0 0 0 0 % R
% Ser: 0 0 0 16 0 0 0 0 0 0 0 0 0 0 77 % S
% Thr: 0 0 0 0 0 0 0 16 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 70 0 0 0 77 0 0 8 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 62 0 0 0 0 70 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _