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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NF1 All Species: 31.52
Human Site: S2768 Identified Species: 69.33
UniProt: P21359 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P21359 NP_000258.1 2839 319372 S2768 P Y P P A L Q S Q L S I T A N
Chimpanzee Pan troglodytes XP_511395 2839 319368 S2768 P Y P P A L Q S Q L S I T A N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537738 2824 317549 S2753 P Y P P A V Q S Q L S I T A N
Cat Felis silvestris
Mouse Mus musculus Q04690 2841 319577 S2770 P Y P P A L Q S Q L S I T A N
Rat Rattus norvegicus P97526 2820 317065 S2749 P Y P P A L Q S Q L S I T A N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506475 2851 320923 S2780 P Y P P A V Q S Q L S I T A N
Chicken Gallus gallus XP_415914 2833 319514 S2762 P Y P P A V Q S Q L S I T A N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_692937 2750 310306 S2679 P Y P P P V Q S Q L S I T A N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001014668 2764 312956 G2694 L H F L Q S C G F G G L W R F
Honey Bee Apis mellifera XP_624747 2748 312616 R2677 I P S E K F K R S D G H Y S D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001197154 1913 215693 N1843 A T I V R N M N G G G V G I L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 98.8 N.A. 98.4 97.8 N.A. 95.3 95.2 N.A. 85.6 N.A. 55.5 56 N.A. 40.3
Protein Similarity: 100 100 N.A. 99.1 N.A. 99.3 98.6 N.A. 97.4 97.8 N.A. 91.3 N.A. 71.2 71.6 N.A. 52.3
P-Site Identity: 100 100 N.A. 93.3 N.A. 100 100 N.A. 93.3 93.3 N.A. 86.6 N.A. 0 0 N.A. 0
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 N.A. 93.3 N.A. 13.3 20 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 64 0 0 0 0 0 0 0 0 73 0 % A
% Cys: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 10 % D
% Glu: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 10 0 0 10 0 0 10 0 0 0 0 0 10 % F
% Gly: 0 0 0 0 0 0 0 10 10 19 28 0 10 0 0 % G
% His: 0 10 0 0 0 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 10 0 10 0 0 0 0 0 0 0 0 73 0 10 0 % I
% Lys: 0 0 0 0 10 0 10 0 0 0 0 0 0 0 0 % K
% Leu: 10 0 0 10 0 37 0 0 0 73 0 10 0 0 10 % L
% Met: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 10 0 10 0 0 0 0 0 0 73 % N
% Pro: 73 10 73 73 10 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 10 0 73 0 73 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 10 0 0 10 0 0 0 0 0 10 0 % R
% Ser: 0 0 10 0 0 10 0 73 10 0 73 0 0 10 0 % S
% Thr: 0 10 0 0 0 0 0 0 0 0 0 0 73 0 0 % T
% Val: 0 0 0 10 0 37 0 0 0 0 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % W
% Tyr: 0 73 0 0 0 0 0 0 0 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _