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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB4
All Species:
35.76
Human Site:
S1019
Identified Species:
65.56
UniProt:
P21439
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21439
NP_000434.1
1286
141523
S1019
E
R
Q
P
L
I
D
S
Y
S
E
E
G
L
K
Chimpanzee
Pan troglodytes
XP_001160982
1599
175326
S1331
E
R
Q
P
L
I
D
S
Y
S
E
E
G
L
K
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
S1023
E
K
T
P
L
I
D
S
Y
S
T
E
G
L
K
Dog
Lupus familis
XP_539461
1269
140189
S1012
E
K
K
P
T
I
D
S
Y
S
Q
E
G
K
K
Cat
Felis silvestris
Mouse
Mus musculus
P21440
1276
140314
S1016
E
R
Q
P
L
I
D
S
Y
S
G
E
G
L
W
Rat
Rattus norvegicus
Q08201
1278
140637
S1018
E
R
Q
P
L
I
D
S
Y
S
R
E
G
M
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
S1108
E
R
K
P
L
V
D
S
C
S
D
R
G
L
K
Chicken
Gallus gallus
XP_418636
1307
144961
S1047
E
R
V
P
L
I
D
S
Y
S
E
E
G
E
K
Frog
Xenopus laevis
NP_001081394
1287
141487
S1029
E
R
V
P
Q
I
D
S
Y
S
D
Q
G
E
K
Zebra Danio
Brachydanio rerio
Q56A55
714
77317
N485
S
Y
P
T
R
P
G
N
Q
I
L
K
H
F
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
T1044
K
I
Q
S
P
M
G
T
I
K
N
T
L
A
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
D1062
L
R
K
I
S
K
I
D
S
L
S
L
A
G
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
S1017
D
R
K
S
K
I
D
S
S
D
E
T
G
T
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.9
75.8
53.9
N.A.
90.2
90.6
N.A.
67.6
70
67
25.1
N.A.
43
N.A.
43.1
N.A.
Protein Similarity:
100
79.4
86.4
73.4
N.A.
95.1
95.2
N.A.
80.9
83.6
80.9
36.7
N.A.
61.6
N.A.
61.2
N.A.
P-Site Identity:
100
100
80
66.6
N.A.
86.6
80
N.A.
66.6
86.6
66.6
0
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
100
86.6
86.6
N.A.
86.6
86.6
N.A.
86.6
86.6
80
13.3
N.A.
33.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
77
8
0
8
16
0
0
0
0
% D
% Glu:
70
0
0
0
0
0
0
0
0
0
31
54
0
16
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
16
0
0
0
8
0
77
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
8
0
8
0
70
8
0
8
8
0
0
0
0
0
% I
% Lys:
8
16
31
0
8
8
0
0
0
8
0
8
0
8
62
% K
% Leu:
8
0
0
0
54
0
0
0
0
8
8
8
8
39
0
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% N
% Pro:
0
0
8
70
8
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
39
0
8
0
0
0
8
0
8
8
0
0
0
% Q
% Arg:
0
70
0
0
8
0
0
0
0
0
8
8
0
0
0
% R
% Ser:
8
0
0
16
8
0
0
77
16
70
8
0
0
0
8
% S
% Thr:
0
0
8
8
8
0
0
8
0
0
8
16
0
8
0
% T
% Val:
0
0
16
0
0
8
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% W
% Tyr:
0
8
0
0
0
0
0
0
62
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _