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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB4
All Species:
12.42
Human Site:
S635
Identified Species:
22.78
UniProt:
P21439
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21439
NP_000434.1
1286
141523
S635
V
N
M
Q
T
S
G
S
Q
I
Q
S
E
E
F
Chimpanzee
Pan troglodytes
XP_001160982
1599
175326
S947
V
N
M
Q
T
S
G
S
Q
I
Q
S
E
E
F
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
I638
M
Q
T
A
G
N
E
I
E
L
E
N
A
A
D
Dog
Lupus familis
XP_539461
1269
140189
Q628
M
T
Q
V
S
D
E
Q
I
E
S
M
A
Y
S
Cat
Felis silvestris
Mouse
Mus musculus
P21440
1276
140314
S632
V
N
M
Q
T
A
G
S
Q
I
L
S
E
E
F
Rat
Rattus norvegicus
Q08201
1278
140637
I634
M
Q
T
S
G
S
Q
I
L
S
E
E
F
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
A724
S
K
L
V
A
M
Q
A
S
G
N
Q
W
E
P
Chicken
Gallus gallus
XP_418636
1307
144961
E663
L
V
N
M
Q
A
S
E
T
E
D
Q
L
Q
E
Frog
Xenopus laevis
NP_001081394
1287
141487
K645
L
Q
T
V
E
T
S
K
D
T
E
E
D
L
E
Zebra Danio
Brachydanio rerio
Q56A55
714
77317
V123
K
V
P
L
E
V
Q
V
K
E
K
I
P
E
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
I656
E
V
E
K
E
D
S
I
E
D
T
K
Q
K
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
S678
N
S
V
A
R
Q
T
S
E
H
E
G
L
S
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
S634
T
S
E
L
S
S
G
S
S
F
R
N
S
N
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.9
75.8
53.9
N.A.
90.2
90.6
N.A.
67.6
70
67
25.1
N.A.
43
N.A.
43.1
N.A.
Protein Similarity:
100
79.4
86.4
73.4
N.A.
95.1
95.2
N.A.
80.9
83.6
80.9
36.7
N.A.
61.6
N.A.
61.2
N.A.
P-Site Identity:
100
100
0
0
N.A.
86.6
13.3
N.A.
6.6
0
0
13.3
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
100
40
13.3
N.A.
93.3
26.6
N.A.
20
20
26.6
26.6
N.A.
26.6
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
16
8
16
0
8
0
0
0
0
16
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
16
0
0
8
8
8
0
8
0
8
% D
% Glu:
8
0
16
0
24
0
16
8
24
24
31
16
24
47
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
31
% F
% Gly:
0
0
0
0
16
0
31
0
0
8
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
24
8
24
0
8
0
0
0
% I
% Lys:
8
8
0
8
0
0
0
8
8
0
8
8
0
8
0
% K
% Leu:
16
0
8
16
0
0
0
0
8
8
8
0
16
8
8
% L
% Met:
24
0
24
8
0
8
0
0
0
0
0
8
0
0
0
% M
% Asn:
8
24
8
0
0
8
0
0
0
0
8
16
0
8
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
8
% P
% Gln:
0
24
8
24
8
8
24
8
24
0
16
16
8
8
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
8
% R
% Ser:
8
16
0
8
16
31
24
39
16
8
8
24
8
8
16
% S
% Thr:
8
8
24
0
24
8
8
0
8
8
8
0
0
0
0
% T
% Val:
24
24
8
24
0
8
0
8
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _