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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB4
All Species:
11.82
Human Site:
S666
Identified Species:
21.67
UniProt:
P21439
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.42
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21439
NP_000434.1
1286
141523
S666
K
S
R
L
F
R
H
S
T
Q
K
N
L
K
N
Chimpanzee
Pan troglodytes
XP_001160982
1599
175326
S978
K
S
R
L
F
R
H
S
T
Q
K
N
L
K
N
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
R669
G
S
S
L
I
R
K
R
S
T
R
R
S
V
R
Dog
Lupus familis
XP_539461
1269
140189
K659
S
K
S
L
I
N
S
K
Y
K
K
P
K
L
H
Cat
Felis silvestris
Mouse
Mus musculus
P21440
1276
140314
R663
G
W
K
A
R
I
F
R
N
S
T
K
K
S
L
Rat
Rattus norvegicus
Q08201
1278
140637
S665
K
A
R
I
F
R
N
S
T
K
K
S
L
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
R755
S
S
N
G
H
V
F
R
R
S
A
R
S
S
V
Chicken
Gallus gallus
XP_418636
1307
144961
S694
L
T
G
Q
K
R
Q
S
T
R
K
S
I
K
R
Frog
Xenopus laevis
NP_001081394
1287
141487
R676
L
V
R
R
K
S
S
R
N
T
I
K
S
K
V
Zebra Danio
Brachydanio rerio
Q56A55
714
77317
F154
M
G
A
I
L
L
A
F
G
A
A
A
L
N
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
Q687
K
G
Q
K
N
S
V
Q
F
E
E
P
I
I
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
P709
I
G
S
I
T
N
G
P
V
I
D
E
K
E
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
L665
H
S
L
N
V
L
G
L
T
T
G
L
D
L
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.9
75.8
53.9
N.A.
90.2
90.6
N.A.
67.6
70
67
25.1
N.A.
43
N.A.
43.1
N.A.
Protein Similarity:
100
79.4
86.4
73.4
N.A.
95.1
95.2
N.A.
80.9
83.6
80.9
36.7
N.A.
61.6
N.A.
61.2
N.A.
P-Site Identity:
100
100
20
13.3
N.A.
0
60
N.A.
6.6
33.3
13.3
6.6
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
33.3
26.6
N.A.
6.6
100
N.A.
6.6
60
13.3
13.3
N.A.
33.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
0
0
8
0
0
8
16
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
8
8
0
8
8
% E
% Phe:
0
0
0
0
24
0
16
8
8
0
0
0
0
0
0
% F
% Gly:
16
24
8
8
0
0
16
0
8
0
8
0
0
0
8
% G
% His:
8
0
0
0
8
0
16
0
0
0
0
0
0
0
8
% H
% Ile:
8
0
0
24
16
8
0
0
0
8
8
0
16
8
8
% I
% Lys:
31
8
8
8
16
0
8
8
0
16
39
16
24
39
8
% K
% Leu:
16
0
8
31
8
16
0
8
0
0
0
8
31
16
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
8
16
8
0
16
0
0
16
0
8
16
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
16
0
0
0
% P
% Gln:
0
0
8
8
0
0
8
8
0
16
0
0
0
0
0
% Q
% Arg:
0
0
31
8
8
39
0
31
8
8
8
16
0
0
16
% R
% Ser:
16
39
24
0
0
16
16
31
8
16
0
16
24
16
8
% S
% Thr:
0
8
0
0
8
0
0
0
39
24
8
0
0
0
0
% T
% Val:
0
8
0
0
8
8
8
0
8
0
0
0
0
8
16
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _