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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCB4 All Species: 11.82
Human Site: S666 Identified Species: 21.67
UniProt: P21439 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.42
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P21439 NP_000434.1 1286 141523 S666 K S R L F R H S T Q K N L K N
Chimpanzee Pan troglodytes XP_001160982 1599 175326 S978 K S R L F R H S T Q K N L K N
Rhesus Macaque Macaca mulatta NP_001028059 1283 141504 R669 G S S L I R K R S T R R S V R
Dog Lupus familis XP_539461 1269 140189 K659 S K S L I N S K Y K K P K L H
Cat Felis silvestris
Mouse Mus musculus P21440 1276 140314 R663 G W K A R I F R N S T K K S L
Rat Rattus norvegicus Q08201 1278 140637 S665 K A R I F R N S T K K S L K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508941 1368 147746 R755 S S N G H V F R R S A R S S V
Chicken Gallus gallus XP_418636 1307 144961 S694 L T G Q K R Q S T R K S I K R
Frog Xenopus laevis NP_001081394 1287 141487 R676 L V R R K S S R N T I K S K V
Zebra Danio Brachydanio rerio Q56A55 714 77317 F154 M G A I L L A F G A A A L N I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q00748 1302 143766 Q687 K G Q K N S V Q F E E P I I K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34712 1321 145045 P709 I G S I T N G P V I D E K E E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FWX7 1278 137648 L665 H S L N V L G L T T G L D L G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 78.9 75.8 53.9 N.A. 90.2 90.6 N.A. 67.6 70 67 25.1 N.A. 43 N.A. 43.1 N.A.
Protein Similarity: 100 79.4 86.4 73.4 N.A. 95.1 95.2 N.A. 80.9 83.6 80.9 36.7 N.A. 61.6 N.A. 61.2 N.A.
P-Site Identity: 100 100 20 13.3 N.A. 0 60 N.A. 6.6 33.3 13.3 6.6 N.A. 6.6 N.A. 0 N.A.
P-Site Similarity: 100 100 33.3 26.6 N.A. 6.6 100 N.A. 6.6 60 13.3 13.3 N.A. 33.3 N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 41.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 62.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 8 0 0 8 0 0 8 16 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 8 0 8 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 8 8 8 0 8 8 % E
% Phe: 0 0 0 0 24 0 16 8 8 0 0 0 0 0 0 % F
% Gly: 16 24 8 8 0 0 16 0 8 0 8 0 0 0 8 % G
% His: 8 0 0 0 8 0 16 0 0 0 0 0 0 0 8 % H
% Ile: 8 0 0 24 16 8 0 0 0 8 8 0 16 8 8 % I
% Lys: 31 8 8 8 16 0 8 8 0 16 39 16 24 39 8 % K
% Leu: 16 0 8 31 8 16 0 8 0 0 0 8 31 16 8 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 8 8 16 8 0 16 0 0 16 0 8 16 % N
% Pro: 0 0 0 0 0 0 0 8 0 0 0 16 0 0 0 % P
% Gln: 0 0 8 8 0 0 8 8 0 16 0 0 0 0 0 % Q
% Arg: 0 0 31 8 8 39 0 31 8 8 8 16 0 0 16 % R
% Ser: 16 39 24 0 0 16 16 31 8 16 0 16 24 16 8 % S
% Thr: 0 8 0 0 8 0 0 0 39 24 8 0 0 0 0 % T
% Val: 0 8 0 0 8 8 8 0 8 0 0 0 0 8 16 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _