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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB4
All Species:
4.55
Human Site:
S680
Identified Species:
8.33
UniProt:
P21439
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21439
NP_000434.1
1286
141523
S680
N
S
Q
M
C
Q
K
S
L
D
V
E
T
D
G
Chimpanzee
Pan troglodytes
XP_001160982
1599
175326
S992
N
S
Q
M
C
Q
K
S
L
D
V
E
T
D
G
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
R683
R
G
S
Q
G
Q
D
R
K
L
S
T
K
E
A
Dog
Lupus familis
XP_539461
1269
140189
N673
H
Y
A
K
A
H
H
N
K
L
K
I
D
C
D
Cat
Felis silvestris
Mouse
Mus musculus
P21440
1276
140314
R677
L
K
S
P
H
Q
N
R
L
D
E
E
T
N
E
Rat
Rattus norvegicus
Q08201
1278
140637
R679
S
S
R
A
H
Q
N
R
L
D
V
E
T
N
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
Q769
V
R
R
S
R
R
D
Q
R
I
P
K
A
E
E
Chicken
Gallus gallus
XP_418636
1307
144961
E708
R
V
R
I
Q
N
D
E
L
D
V
K
A
D
Q
Frog
Xenopus laevis
NP_001081394
1287
141487
E690
V
P
E
T
E
D
K
E
V
D
E
E
E
K
K
Zebra Danio
Brachydanio rerio
Q56A55
714
77317
G168
I
Q
I
P
L
M
L
G
D
L
V
N
V
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
N701
K
A
L
I
K
D
T
N
A
Q
S
A
E
A
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
L723
E
R
I
G
K
D
A
L
S
R
L
K
Q
E
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
G679
G
S
H
S
Q
R
A
G
Q
D
E
T
G
T
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.9
75.8
53.9
N.A.
90.2
90.6
N.A.
67.6
70
67
25.1
N.A.
43
N.A.
43.1
N.A.
Protein Similarity:
100
79.4
86.4
73.4
N.A.
95.1
95.2
N.A.
80.9
83.6
80.9
36.7
N.A.
61.6
N.A.
61.2
N.A.
P-Site Identity:
100
100
6.6
0
N.A.
33.3
46.6
N.A.
0
26.6
20
6.6
N.A.
0
N.A.
0
N.A.
P-Site Similarity:
100
100
13.3
13.3
N.A.
40
66.6
N.A.
26.6
46.6
33.3
6.6
N.A.
20
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
8
0
16
0
8
0
0
8
16
8
24
% A
% Cys:
0
0
0
0
16
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
0
24
24
0
8
54
0
0
8
24
8
% D
% Glu:
8
0
8
0
8
0
0
16
0
0
24
39
16
24
24
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
8
0
8
8
0
0
16
0
0
0
0
8
0
16
% G
% His:
8
0
8
0
16
8
8
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
16
16
0
0
0
0
0
8
0
8
0
0
0
% I
% Lys:
8
8
0
8
16
0
24
0
16
0
8
24
8
8
8
% K
% Leu:
8
0
8
0
8
0
8
8
39
24
8
0
0
0
8
% L
% Met:
0
0
0
16
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
16
0
0
0
0
8
16
16
0
0
0
8
0
16
0
% N
% Pro:
0
8
0
16
0
0
0
0
0
0
8
0
0
0
8
% P
% Gln:
0
8
16
8
16
39
0
8
8
8
0
0
8
0
8
% Q
% Arg:
16
16
24
0
8
16
0
24
8
8
0
0
0
0
0
% R
% Ser:
8
31
16
16
0
0
0
16
8
0
16
0
0
0
0
% S
% Thr:
0
0
0
8
0
0
8
0
0
0
0
16
31
8
0
% T
% Val:
16
8
0
0
0
0
0
0
8
0
39
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _