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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB4
All Species:
10.3
Human Site:
Y116
Identified Species:
18.89
UniProt:
P21439
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21439
NP_000434.1
1286
141523
Y116
L
E
E
E
M
T
R
Y
A
Y
Y
Y
S
G
L
Chimpanzee
Pan troglodytes
XP_001160982
1599
175326
Y428
L
E
E
E
M
T
R
Y
A
Y
Y
Y
S
G
L
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
Y117
L
E
E
D
M
T
R
Y
A
Y
Y
Y
S
G
I
Dog
Lupus familis
XP_539461
1269
140189
L118
I
G
I
G
V
T
A
L
V
F
G
Y
I
Q
I
Cat
Felis silvestris
Mouse
Mus musculus
P21440
1276
140314
Y116
E
M
T
R
Y
A
Y
Y
Y
S
G
L
G
G
G
Rat
Rattus norvegicus
Q08201
1278
140637
Y116
E
M
T
R
Y
A
Y
Y
Y
S
G
L
G
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
A209
E
E
E
M
T
R
Y
A
W
Y
Y
S
G
L
G
Chicken
Gallus gallus
XP_418636
1307
144961
I134
M
E
F
F
S
Y
L
I
L
G
E
L
E
E
E
Frog
Xenopus laevis
NP_001081394
1287
141487
A125
Q
G
Q
M
T
T
Y
A
Y
Y
Y
S
G
L
G
Zebra Danio
Brachydanio rerio
Q56A55
714
77317
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
G121
Y
D
D
S
I
S
Y
G
I
L
L
T
I
A
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
M136
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
A117
G
L
G
T
L
G
A
A
F
L
Q
V
A
C
W
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.9
75.8
53.9
N.A.
90.2
90.6
N.A.
67.6
70
67
25.1
N.A.
43
N.A.
43.1
N.A.
Protein Similarity:
100
79.4
86.4
73.4
N.A.
95.1
95.2
N.A.
80.9
83.6
80.9
36.7
N.A.
61.6
N.A.
61.2
N.A.
P-Site Identity:
100
100
86.6
13.3
N.A.
13.3
13.3
N.A.
26.6
6.6
20
0
N.A.
0
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
40
N.A.
13.3
13.3
N.A.
26.6
13.3
26.6
0
N.A.
26.6
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
16
16
24
24
0
0
0
8
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
16
8
8
0
8
0
0
0
0
0
0
0
0
0
% D
% Glu:
24
39
31
24
0
0
0
0
0
0
8
0
8
8
8
% E
% Phe:
0
0
16
8
0
0
0
0
8
8
0
0
0
0
0
% F
% Gly:
8
16
8
8
0
8
0
8
0
8
24
0
31
39
31
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
8
0
8
0
0
8
8
0
0
0
16
0
16
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
24
8
0
0
8
0
8
8
8
16
8
24
0
16
16
% L
% Met:
8
16
0
16
24
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
8
0
0
0
0
0
0
0
8
0
0
8
0
% Q
% Arg:
0
0
0
16
0
8
24
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
8
8
8
0
0
0
16
0
16
31
0
8
% S
% Thr:
8
0
16
8
16
39
0
0
0
0
0
8
0
0
0
% T
% Val:
0
0
0
0
8
0
8
0
8
8
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
8
% W
% Tyr:
8
0
0
0
16
8
39
39
24
39
39
31
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _