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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB4
All Species:
4.55
Human Site:
Y924
Identified Species:
8.33
UniProt:
P21439
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21439
NP_000434.1
1286
141523
Y924
S
M
Y
V
E
K
L
Y
G
P
Y
R
N
S
V
Chimpanzee
Pan troglodytes
XP_001160982
1599
175326
Y1236
S
M
Y
V
E
K
L
Y
G
P
Y
R
N
S
V
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
Q928
H
M
Y
D
Q
S
L
Q
V
P
Y
R
N
S
L
Dog
Lupus familis
XP_539461
1269
140189
Q917
Q
T
Y
E
E
T
L
Q
A
Q
H
R
N
T
L
Cat
Felis silvestris
Mouse
Mus musculus
P21440
1276
140314
H921
S
M
Y
V
E
K
L
H
G
P
Y
R
N
S
V
Rat
Rattus norvegicus
Q08201
1278
140637
H923
S
M
Y
V
E
K
L
H
G
P
Y
R
N
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
L1013
S
T
Y
G
E
S
L
L
G
P
Y
R
N
S
V
Chicken
Gallus gallus
XP_418636
1307
144961
Q952
Y
M
Y
G
Q
N
L
Q
V
S
Y
R
N
S
I
Frog
Xenopus laevis
NP_001081394
1287
141487
E933
A
M
Y
E
K
S
L
E
G
P
Y
R
N
S
I
Zebra Danio
Brachydanio rerio
Q56A55
714
77317
F393
C
I
V
L
G
T
I
F
A
G
G
S
L
M
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
Q945
R
E
Y
T
E
E
I
Q
R
V
E
V
L
I
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
D966
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
E922
Q
M
Y
K
K
Q
C
E
G
P
I
K
D
G
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.9
75.8
53.9
N.A.
90.2
90.6
N.A.
67.6
70
67
25.1
N.A.
43
N.A.
43.1
N.A.
Protein Similarity:
100
79.4
86.4
73.4
N.A.
95.1
95.2
N.A.
80.9
83.6
80.9
36.7
N.A.
61.6
N.A.
61.2
N.A.
P-Site Identity:
100
100
53.3
33.3
N.A.
93.3
93.3
N.A.
73.3
46.6
60
0
N.A.
13.3
N.A.
26.6
N.A.
P-Site Similarity:
100
100
66.6
53.3
N.A.
100
100
N.A.
73.3
60
80
26.6
N.A.
26.6
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
16
0
0
0
0
8
8
% A
% Cys:
8
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
8
0
0
0
0
8
0
0
% D
% Glu:
8
8
0
16
62
8
0
16
0
0
8
0
8
0
0
% E
% Phe:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
16
8
0
0
0
54
8
8
0
0
8
0
% G
% His:
8
0
0
0
0
0
0
16
0
0
16
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
16
0
8
0
8
0
0
8
31
% I
% Lys:
0
0
0
8
16
39
0
0
0
0
0
16
0
0
0
% K
% Leu:
0
0
0
8
0
0
77
8
0
0
0
0
16
0
16
% L
% Met:
0
62
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
8
0
0
0
8
0
0
0
0
0
0
70
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
70
0
0
0
0
0
% P
% Gln:
16
0
0
0
16
8
0
31
0
8
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
8
0
0
70
0
0
8
% R
% Ser:
39
0
0
0
0
24
0
0
0
8
0
8
0
62
0
% S
% Thr:
0
16
0
8
0
16
0
0
0
0
0
0
0
8
0
% T
% Val:
0
0
8
31
0
0
0
0
16
8
0
8
0
0
39
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
85
0
0
0
0
16
0
0
62
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _