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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB4
All Species:
40.61
Human Site:
Y997
Identified Species:
74.44
UniProt:
P21439
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21439
NP_000434.1
1286
141523
Y997
A
S
S
F
A
P
D
Y
A
K
A
K
L
S
A
Chimpanzee
Pan troglodytes
XP_001160982
1599
175326
Y1309
A
S
S
F
A
P
D
Y
A
K
A
K
L
S
A
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
Y1001
V
S
S
F
A
P
D
Y
A
K
A
K
V
S
A
Dog
Lupus familis
XP_539461
1269
140189
Y990
T
L
V
L
A
P
E
Y
S
R
A
K
S
G
A
Cat
Felis silvestris
Mouse
Mus musculus
P21440
1276
140314
Y994
A
S
S
F
A
P
D
Y
A
K
A
K
L
S
A
Rat
Rattus norvegicus
Q08201
1278
140637
Y996
A
S
S
F
A
P
D
Y
A
K
A
K
L
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
Y1086
A
S
S
F
A
P
D
Y
A
R
A
K
L
A
A
Chicken
Gallus gallus
XP_418636
1307
144961
Y1025
S
T
S
F
T
P
D
Y
A
K
A
K
M
S
A
Frog
Xenopus laevis
NP_001081394
1287
141487
Y1007
T
S
S
F
A
P
D
Y
T
K
A
M
I
S
A
Zebra Danio
Brachydanio rerio
Q56A55
714
77317
D464
G
G
G
R
I
P
L
D
S
L
M
G
R
V
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
F1018
S
L
A
F
T
P
A
F
S
A
A
L
I
A
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
Y1041
A
T
S
Y
F
P
E
Y
A
K
A
T
F
A
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
S995
S
S
T
F
A
P
D
S
S
K
A
K
V
A
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.9
75.8
53.9
N.A.
90.2
90.6
N.A.
67.6
70
67
25.1
N.A.
43
N.A.
43.1
N.A.
Protein Similarity:
100
79.4
86.4
73.4
N.A.
95.1
95.2
N.A.
80.9
83.6
80.9
36.7
N.A.
61.6
N.A.
61.2
N.A.
P-Site Identity:
100
100
86.6
40
N.A.
100
100
N.A.
86.6
73.3
73.3
6.6
N.A.
20
N.A.
46.6
N.A.
P-Site Similarity:
100
100
93.3
60
N.A.
100
100
N.A.
100
93.3
80
13.3
N.A.
60
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
93.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
0
8
0
70
0
8
0
62
8
93
0
0
31
77
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
70
8
0
0
0
0
0
0
8
% D
% Glu:
0
0
0
0
0
0
16
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
77
8
0
0
8
0
0
0
0
8
0
0
% F
% Gly:
8
8
8
0
0
0
0
0
0
0
0
8
0
8
16
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
0
0
0
0
16
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
70
0
70
0
0
0
% K
% Leu:
0
16
0
8
0
0
8
0
0
8
0
8
39
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
8
8
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
100
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
16
0
0
8
0
0
% R
% Ser:
24
62
70
0
0
0
0
8
31
0
0
0
8
54
0
% S
% Thr:
16
16
8
0
16
0
0
0
8
0
0
8
0
0
0
% T
% Val:
8
0
8
0
0
0
0
0
0
0
0
0
16
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
77
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _