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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MDK All Species: 17.27
Human Site: S35 Identified Species: 42.22
UniProt: P21741 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P21741 NP_001012333.1 143 15585 S35 V K K G G P G S E C A E W A W
Chimpanzee Pan troglodytes XP_001149958 225 24069 Q117 P V S T K F H Q I Q A C G L L
Rhesus Macaque Macaca mulatta XP_001112400 166 17706 S35 V K K G G P G S E C A E W A W
Dog Lupus familis XP_851259 143 15443 E35 V T K G G P G E R V R G V D L
Cat Felis silvestris
Mouse Mus musculus P12025 140 15415 S32 K E K V K K G S E C S E W T W
Rat Rattus norvegicus Q9R1S9 140 15387 S32 K D K V K K G S E C S E W T W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513099 228 25087 S60 P E K K A K K S D C G E W Q W
Chicken Gallus gallus P24052 142 15561 S34 E K M K K E G S E C Q D W H W
Frog Xenopus laevis P48531 142 15577 S34 E K G K K G A S D C T E W T W
Zebra Danio Brachydanio rerio NP_571145 146 15762 A37 N K G G K G G A D C A E W L Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 45.7 83.1 66.4 N.A. 86 86.7 N.A. 32.4 64.3 60.8 58.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 50.6 84.9 69.2 N.A. 91.6 92.3 N.A. 45.1 79.7 78.3 72.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 100 40 N.A. 53.3 53.3 N.A. 40 46.6 40 46.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 6.6 100 40 N.A. 66.6 60 N.A. 53.3 53.3 46.6 66.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 10 10 0 0 40 0 0 20 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 80 0 10 0 0 0 % C
% Asp: 0 10 0 0 0 0 0 0 30 0 0 10 0 10 0 % D
% Glu: 20 20 0 0 0 10 0 10 50 0 0 70 0 0 0 % E
% Phe: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 20 40 30 20 70 0 0 0 10 10 10 0 0 % G
% His: 0 0 0 0 0 0 10 0 0 0 0 0 0 10 0 % H
% Ile: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % I
% Lys: 20 50 60 30 60 30 10 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 20 20 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 20 0 0 0 0 30 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 10 0 10 10 0 0 10 0 % Q
% Arg: 0 0 0 0 0 0 0 0 10 0 10 0 0 0 0 % R
% Ser: 0 0 10 0 0 0 0 70 0 0 20 0 0 0 0 % S
% Thr: 0 10 0 10 0 0 0 0 0 0 10 0 0 30 0 % T
% Val: 30 10 0 20 0 0 0 0 0 10 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 80 0 70 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _