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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
COMT
All Species:
9.7
Human Site:
S267
Identified Species:
23.72
UniProt:
P21964
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21964
NP_000745.1
271
30037
S267
A
I
Y
K
G
P
G
S
E
A
G
P
_
_
_
Chimpanzee
Pan troglodytes
P86243
291
32105
T286
K
D
G
I
A
Q
L
T
Y
A
G
P
G
_
_
Rhesus Macaque
Macaca mulatta
B6CZ46
296
32648
Dog
Lupus familis
XP_542328
258
28816
T253
K
D
G
I
A
Q
L
T
Y
A
G
P
G
_
_
Cat
Felis silvestris
Mouse
Mus musculus
O88587
265
29478
S260
A
V
Y
Q
G
P
G
S
S
P
V
K
S
_
_
Rat
Rattus norvegicus
P22734
264
29579
S260
A
I
Y
Q
G
P
S
S
P
D
K
S
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521002
531
58943
Chicken
Gallus gallus
XP_415077
262
29770
Frog
Xenopus laevis
NP_001079715
261
29419
Zebra Danio
Brachydanio rerio
NP_001077312
264
29853
S260
A
E
D
G
L
E
K
S
V
F
L
G
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
34.7
31.7
34.6
N.A.
77.1
76.3
N.A.
28.2
54.9
51.2
50.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
55.3
52.7
57.2
N.A.
87.8
87.8
N.A.
39.1
73.4
71.5
68.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
23
0
23
N.A.
46.1
50
N.A.
0
0
0
16.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
38.4
0
38.4
N.A.
61.5
58.3
N.A.
0
0
0
16.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
40
0
0
0
20
0
0
0
0
30
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
20
10
0
0
0
0
0
0
10
0
0
0
0
0
% D
% Glu:
0
10
0
0
0
10
0
0
10
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
0
20
10
30
0
20
0
0
0
30
10
20
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
20
0
20
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
20
0
0
10
0
0
10
0
0
0
10
10
0
0
0
% K
% Leu:
0
0
0
0
10
0
20
0
0
0
10
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
30
0
0
10
10
0
30
0
0
0
% P
% Gln:
0
0
0
20
0
20
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
10
40
10
0
0
10
10
0
0
% S
% Thr:
0
0
0
0
0
0
0
20
0
0
0
0
0
0
0
% T
% Val:
0
10
0
0
0
0
0
0
10
0
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
30
0
0
0
0
0
20
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
30
60
60
% _