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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
OSBP
All Species:
17.27
Human Site:
T561
Identified Species:
31.67
UniProt:
P22059
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22059
NP_002547.1
807
89421
T561
L
S
I
M
P
L
G
T
I
H
C
I
F
H
A
Chimpanzee
Pan troglodytes
XP_508451
807
89429
T561
L
S
I
M
P
L
G
T
I
H
C
I
F
H
A
Rhesus Macaque
Macaca mulatta
XP_001090190
805
89207
T559
L
S
I
M
P
L
G
T
I
H
C
I
F
H
A
Dog
Lupus familis
XP_540566
1109
121200
S863
L
S
I
M
P
L
G
S
I
H
C
I
F
H
A
Cat
Felis silvestris
Mouse
Mus musculus
Q3B7Z2
751
84671
K521
G
H
H
Y
T
W
K
K
V
T
T
T
V
H
N
Rat
Rattus norvegicus
Q8K4M9
950
107747
T691
V
E
A
E
P
K
G
T
I
T
L
E
L
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505999
738
84284
L521
H
N
I
I
V
G
K
L
W
I
D
Q
S
G
E
Chicken
Gallus gallus
XP_415293
788
88247
A541
L
S
I
M
P
L
G
A
I
H
L
E
F
H
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001139057
760
85799
T529
Y
T
W
K
K
V
T
T
T
V
H
N
I
I
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477271
784
89306
V542
Q
I
N
P
L
G
G
V
Y
V
Q
F
P
N
S
Honey Bee
Apis mellifera
XP_392480
836
95642
A597
Q
V
I
P
L
G
T
A
H
L
E
I
D
G
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_790853
566
64483
I356
W
S
I
I
K
N
C
I
G
K
E
L
S
R
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P35845
1188
135079
Y942
V
Q
H
L
G
L
W
Y
I
T
I
R
P
D
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.5
71.2
N.A.
90.5
29.4
N.A.
83.8
68.9
N.A.
68.4
N.A.
34.3
49.6
N.A.
42.8
Protein Similarity:
100
100
99.7
72.3
N.A.
91.9
42.8
N.A.
86.4
78.9
N.A.
78
N.A.
50.9
64
N.A.
52.9
P-Site Identity:
100
100
100
93.3
N.A.
6.6
26.6
N.A.
6.6
73.3
N.A.
6.6
N.A.
6.6
13.3
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
13.3
33.3
N.A.
20
80
N.A.
20
N.A.
20
13.3
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
16
0
0
0
0
0
0
31
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
31
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
8
0
8
8
0
% D
% Glu:
0
8
0
8
0
0
0
0
0
0
16
16
0
0
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
8
39
0
0
% F
% Gly:
8
0
0
0
8
24
54
0
8
0
0
0
0
16
0
% G
% His:
8
8
16
0
0
0
0
0
8
39
8
0
0
47
8
% H
% Ile:
0
8
62
16
0
0
0
8
54
8
8
39
8
8
8
% I
% Lys:
0
0
0
8
16
8
16
8
0
8
0
0
0
0
0
% K
% Leu:
39
0
0
8
16
47
0
8
0
8
16
8
8
8
0
% L
% Met:
0
0
0
39
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
0
8
0
0
0
0
0
8
0
8
8
% N
% Pro:
0
0
0
16
47
0
0
0
0
0
0
0
16
0
0
% P
% Gln:
16
8
0
0
0
0
0
0
0
0
8
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% R
% Ser:
0
47
0
0
0
0
0
8
0
0
0
0
16
0
16
% S
% Thr:
0
8
0
0
8
0
16
39
8
24
8
8
0
0
8
% T
% Val:
16
8
0
0
8
8
0
8
8
16
0
0
8
0
8
% V
% Trp:
8
0
8
0
0
8
8
0
8
0
0
0
0
0
0
% W
% Tyr:
8
0
0
8
0
0
0
8
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _