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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACHE
All Species:
44.85
Human Site:
S249
Identified Species:
75.9
UniProt:
P22303
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22303
NP_000656.1
614
67796
S249
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
Chimpanzee
Pan troglodytes
XP_516857
643
72946
S282
L
H
L
L
S
P
G
S
H
S
L
F
T
R
A
Rhesus Macaque
Macaca mulatta
NP_001121560
614
67754
S249
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
Dog
Lupus familis
XP_546946
611
67308
S246
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
Cat
Felis silvestris
Mouse
Mus musculus
P21836
614
68150
S249
M
H
I
L
S
L
P
S
R
S
L
F
H
R
A
Rat
Rattus norvegicus
P37136
614
68178
S249
M
H
I
L
S
L
P
S
R
S
L
F
H
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505841
602
68511
S241
F
H
I
L
S
P
K
S
H
P
F
F
T
R
A
Chicken
Gallus gallus
P36196
767
83002
S242
F
H
L
L
S
P
H
S
K
G
L
F
R
R
A
Frog
Xenopus laevis
NP_001121332
600
68177
S239
M
H
V
I
S
P
G
S
H
H
L
F
S
K
A
Zebra Danio
Brachydanio rerio
Q9DDE3
634
71980
S240
M
H
V
L
S
P
D
S
R
P
L
F
T
R
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07140
649
71767
T291
A
Q
L
M
S
P
V
T
R
G
L
V
K
R
G
Honey Bee
Apis mellifera
XP_393751
657
73886
S278
M
H
L
L
S
P
L
S
R
H
L
F
N
Q
A
Nematode Worm
Caenorhab. elegans
P38433
620
71415
S231
I
H
M
L
S
P
K
S
A
P
Y
F
H
R
A
Sea Urchin
Strong. purpuratus
XP_782113
508
56946
S188
L
A
M
G
Q
D
S
S
P
G
N
Q
G
L
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
99.5
92.8
N.A.
88.4
88.5
N.A.
50.6
47.9
59.6
60
N.A.
34.3
39.8
41.2
37.7
Protein Similarity:
100
66.8
99.6
96
N.A.
93
93.6
N.A.
68.2
58
73.4
73.6
N.A.
51.4
56.9
56.9
51.6
P-Site Identity:
100
66.6
100
100
N.A.
80
80
N.A.
53.3
73.3
53.3
73.3
N.A.
46.6
73.3
60
13.3
P-Site Similarity:
100
73.3
100
100
N.A.
86.6
86.6
N.A.
60
80
73.3
80
N.A.
60
86.6
73.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
0
0
8
0
0
0
0
0
86
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
15
0
0
0
0
0
0
0
0
0
8
86
0
0
0
% F
% Gly:
0
0
0
8
0
0
15
0
0
43
0
0
8
0
8
% G
% His:
0
86
0
0
0
0
8
0
22
15
0
0
43
0
0
% H
% Ile:
8
0
22
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
15
0
8
0
0
0
8
8
0
% K
% Leu:
15
0
50
79
0
15
8
0
0
0
79
0
0
8
0
% L
% Met:
58
0
15
8
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% N
% Pro:
0
0
0
0
0
79
36
0
8
22
0
0
0
0
0
% P
% Gln:
0
8
0
0
8
0
0
0
0
0
0
8
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
58
0
0
0
8
79
0
% R
% Ser:
0
0
0
0
93
0
8
93
0
22
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
0
0
22
0
0
% T
% Val:
0
0
15
0
0
0
8
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _