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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACHE
All Species:
25.76
Human Site:
S543
Identified Species:
43.59
UniProt:
P22303
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22303
NP_000656.1
614
67796
S543
A
G
A
Q
Q
Y
V
S
L
D
L
R
P
L
E
Chimpanzee
Pan troglodytes
XP_516857
643
72946
T571
S
T
E
Q
K
Y
L
T
L
N
T
E
S
T
R
Rhesus Macaque
Macaca mulatta
NP_001121560
614
67754
S543
A
G
A
Q
Q
Y
V
S
L
D
L
R
P
L
E
Dog
Lupus familis
XP_546946
611
67308
S540
A
G
A
Q
Q
Y
V
S
L
N
L
R
P
L
E
Cat
Felis silvestris
Mouse
Mus musculus
P21836
614
68150
S543
T
A
A
Q
Q
Y
V
S
L
N
L
K
P
L
E
Rat
Rattus norvegicus
P37136
614
68178
S543
T
A
A
Q
Q
Y
V
S
L
N
L
K
P
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505841
602
68511
T530
S
T
E
Q
K
Y
L
T
M
N
T
D
S
P
K
Chicken
Gallus gallus
P36196
767
83002
H696
P
S
G
Q
R
Y
A
H
L
N
A
R
P
L
S
Frog
Xenopus laevis
NP_001121332
600
68177
A529
A
S
E
Q
R
Y
I
A
L
N
N
R
P
Q
Q
Zebra Danio
Brachydanio rerio
Q9DDE3
634
71980
G563
A
N
E
Q
K
H
V
G
L
N
T
E
P
M
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07140
649
71767
T582
P
V
Y
Y
I
F
S
T
D
D
K
I
E
K
L
Honey Bee
Apis mellifera
XP_393751
657
73886
T571
A
A
K
K
E
Y
M
T
L
D
T
N
S
S
E
Nematode Worm
Caenorhab. elegans
P38433
620
71415
N536
S
V
S
M
E
Y
M
N
M
T
V
E
S
S
Y
Sea Urchin
Strong. purpuratus
XP_782113
508
56946
E453
V
Y
Y
Y
R
F
L
E
R
D
S
T
S
P
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
99.5
92.8
N.A.
88.4
88.5
N.A.
50.6
47.9
59.6
60
N.A.
34.3
39.8
41.2
37.7
Protein Similarity:
100
66.8
99.6
96
N.A.
93
93.6
N.A.
68.2
58
73.4
73.6
N.A.
51.4
56.9
56.9
51.6
P-Site Identity:
100
20
100
93.3
N.A.
73.3
73.3
N.A.
13.3
40
40
33.3
N.A.
6.6
33.3
6.6
6.6
P-Site Similarity:
100
53.3
100
100
N.A.
86.6
86.6
N.A.
60
53.3
73.3
66.6
N.A.
20
60
53.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
43
22
36
0
0
0
8
8
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
8
36
0
8
0
0
0
% D
% Glu:
0
0
29
0
15
0
0
8
0
0
0
22
8
0
43
% E
% Phe:
0
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
22
8
0
0
0
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
8
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
8
8
22
0
0
0
0
0
8
15
0
8
15
% K
% Leu:
0
0
0
0
0
0
22
0
72
0
36
0
0
43
8
% L
% Met:
0
0
0
8
0
0
15
0
15
0
0
0
0
8
0
% M
% Asn:
0
8
0
0
0
0
0
8
0
58
8
8
0
0
0
% N
% Pro:
15
0
0
0
0
0
0
0
0
0
0
0
58
15
0
% P
% Gln:
0
0
0
72
36
0
0
0
0
0
0
0
0
8
8
% Q
% Arg:
0
0
0
0
22
0
0
0
8
0
0
36
0
0
8
% R
% Ser:
22
15
8
0
0
0
8
36
0
0
8
0
36
15
8
% S
% Thr:
15
15
0
0
0
0
0
29
0
8
29
8
0
8
0
% T
% Val:
8
15
0
0
0
0
43
0
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
8
15
15
0
79
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _