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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ACHE All Species: 26.06
Human Site: T269 Identified Species: 44.1
UniProt: P22303 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22303 NP_000656.1 614 67796 T269 A P N G P W A T V G M G E A R
Chimpanzee Pan troglodytes XP_516857 643 72946 V302 S F N A P W A V T S L Y E A R
Rhesus Macaque Macaca mulatta NP_001121560 614 67754 T269 A P N G P W A T V G M G E A R
Dog Lupus familis XP_546946 611 67308 T266 A P N G P W A T V G V G E A R
Cat Felis silvestris
Mouse Mus musculus P21836 614 68150 T269 T P N G P W A T V S A G E A R
Rat Rattus norvegicus P37136 614 68178 T269 T P N G P W A T V S A G E A R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505841 602 68511 A261 S S N A P W A A V P P S E A K
Chicken Gallus gallus P36196 767 83002 T262 S P N G P W A T I G A A E G R
Frog Xenopus laevis NP_001121332 600 68177 T259 T P N T P W A T I T P Q E A R
Zebra Danio Brachydanio rerio Q9DDE3 634 71980 T260 V P N T P W A T V T F D E A R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07140 649 71767 H311 T M N A P W S H M T S E K A V
Honey Bee Apis mellifera XP_393751 657 73886 I298 S P T A P W A I I S R E E S I
Nematode Worm Caenorhab. elegans P38433 620 71415 I251 S A T S P W A I E P R D V A L
Sea Urchin Strong. purpuratus XP_782113 508 56946 I208 M R W V Q D N I H E F G G D P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 48.9 99.5 92.8 N.A. 88.4 88.5 N.A. 50.6 47.9 59.6 60 N.A. 34.3 39.8 41.2 37.7
Protein Similarity: 100 66.8 99.6 96 N.A. 93 93.6 N.A. 68.2 58 73.4 73.6 N.A. 51.4 56.9 56.9 51.6
P-Site Identity: 100 46.6 100 93.3 N.A. 80 80 N.A. 46.6 66.6 60 66.6 N.A. 26.6 33.3 26.6 6.6
P-Site Similarity: 100 60 100 100 N.A. 80 80 N.A. 60 80 66.6 66.6 N.A. 46.6 53.3 33.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 22 8 0 29 0 0 86 8 0 0 22 8 0 79 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 8 0 0 0 0 0 15 0 8 0 % D
% Glu: 0 0 0 0 0 0 0 0 8 8 0 15 79 0 0 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 15 0 0 0 0 % F
% Gly: 0 0 0 43 0 0 0 0 0 29 0 43 8 8 0 % G
% His: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 22 22 0 0 0 0 0 8 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 8 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 8 % L
% Met: 8 8 0 0 0 0 0 0 8 0 15 0 0 0 0 % M
% Asn: 0 0 79 0 0 0 8 0 0 0 0 0 0 0 0 % N
% Pro: 0 65 0 0 93 0 0 0 0 15 15 0 0 0 8 % P
% Gln: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % Q
% Arg: 0 8 0 0 0 0 0 0 0 0 15 0 0 0 65 % R
% Ser: 36 8 0 8 0 0 8 0 0 29 8 8 0 8 0 % S
% Thr: 29 0 15 15 0 0 0 58 8 22 0 0 0 0 0 % T
% Val: 8 0 0 8 0 0 0 8 50 0 8 0 8 0 8 % V
% Trp: 0 0 8 0 0 93 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _