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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACHE
All Species:
18.18
Human Site:
T298
Identified Species:
30.77
UniProt:
P22303
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22303
NP_000656.1
614
67796
T298
G
G
T
G
G
N
D
T
E
L
V
A
C
L
R
Chimpanzee
Pan troglodytes
XP_516857
643
72946
K331
E
N
E
T
E
I
I
K
C
L
R
N
K
D
S
Rhesus Macaque
Macaca mulatta
NP_001121560
614
67754
T298
G
G
T
G
G
N
D
T
E
L
V
A
C
L
R
Dog
Lupus familis
XP_546946
611
67308
T295
G
G
A
G
G
N
D
T
E
L
V
A
C
L
R
Cat
Felis silvestris
Mouse
Mus musculus
P21836
614
68150
T298
G
G
A
G
G
N
D
T
E
L
I
A
C
L
R
Rat
Rattus norvegicus
P37136
614
68178
T298
G
G
A
G
G
N
D
T
E
L
I
S
C
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505841
602
68511
K290
D
N
E
T
Q
L
I
K
C
L
Q
D
K
H
P
Chicken
Gallus gallus
P36196
767
83002
G291
G
N
E
T
E
F
L
G
C
L
R
G
K
E
A
Frog
Xenopus laevis
NP_001121332
600
68177
N288
G
N
D
T
E
L
L
N
C
L
R
A
K
Q
P
Zebra Danio
Brachydanio rerio
Q9DDE3
634
71980
D289
G
N
D
T
E
L
I
D
C
L
R
N
K
H
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07140
649
71767
A340
S
M
L
K
T
N
P
A
H
V
M
S
C
M
R
Honey Bee
Apis mellifera
XP_393751
657
73886
V327
D
R
D
N
L
Q
E
V
I
D
C
L
R
V
K
Nematode Worm
Caenorhab. elegans
P38433
620
71415
Y280
M
S
L
I
N
P
D
Y
D
R
I
L
D
C
F
Sea Urchin
Strong. purpuratus
XP_782113
508
56946
P237
V
S
L
H
L
L
S
P
I
S
R
N
L
F
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
99.5
92.8
N.A.
88.4
88.5
N.A.
50.6
47.9
59.6
60
N.A.
34.3
39.8
41.2
37.7
Protein Similarity:
100
66.8
99.6
96
N.A.
93
93.6
N.A.
68.2
58
73.4
73.6
N.A.
51.4
56.9
56.9
51.6
P-Site Identity:
100
6.6
100
93.3
N.A.
86.6
80
N.A.
6.6
13.3
20
13.3
N.A.
20
0
6.6
0
P-Site Similarity:
100
6.6
100
93.3
N.A.
93.3
93.3
N.A.
6.6
13.3
20
13.3
N.A.
46.6
20
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
22
0
0
0
0
8
0
0
0
36
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
36
0
8
0
43
8
0
% C
% Asp:
15
0
22
0
0
0
43
8
8
8
0
8
8
8
0
% D
% Glu:
8
0
22
0
29
0
8
0
36
0
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
8
% F
% Gly:
58
36
0
36
36
0
0
8
0
0
0
8
0
0
0
% G
% His:
0
0
0
8
0
0
0
0
8
0
0
0
0
15
0
% H
% Ile:
0
0
0
8
0
8
22
0
15
0
22
0
0
0
0
% I
% Lys:
0
0
0
8
0
0
0
15
0
0
0
0
36
0
8
% K
% Leu:
0
0
22
0
15
29
15
0
0
72
0
15
8
36
0
% L
% Met:
8
8
0
0
0
0
0
0
0
0
8
0
0
8
0
% M
% Asn:
0
36
0
8
8
43
0
8
0
0
0
22
0
0
0
% N
% Pro:
0
0
0
0
0
8
8
8
0
0
0
0
0
0
22
% P
% Gln:
0
0
0
0
8
8
0
0
0
0
8
0
0
8
8
% Q
% Arg:
0
8
0
0
0
0
0
0
0
8
36
0
8
0
43
% R
% Ser:
8
15
0
0
0
0
8
0
0
8
0
15
0
0
8
% S
% Thr:
0
0
15
36
8
0
0
36
0
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
0
0
8
0
8
22
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _