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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IDS All Species: 21.21
Human Site: S464 Identified Species: 46.67
UniProt: P22304 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22304 NP_000193.1 550 61873 S464 P R E L I A Y S Q Y P R P S D
Chimpanzee Pan troglodytes XP_521297 659 72527 S573 P R E L I A Y S Q Y P R P S D
Rhesus Macaque Macaca mulatta XP_001089323 550 61783 S464 P R E L I A Y S Q Y P R P A D
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q08890 552 62154 S466 P R E L I A Y S Q Y P R P A D
Rat Rattus norvegicus P15589 577 62660 S477 P N F D P P G S N G C F S T H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512557 523 58748 S436 P L D L V A Y S Q Y P R P A V
Chicken Gallus gallus Q5ZK90 535 61383 V453 D P D E L T N V A I K F P E T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q08CJ7 523 59480 L441 L S K D E S E L R N I A S Q F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_647814 512 58886 N430 M L P T K H P N S D K P K L R
Honey Bee Apis mellifera XP_001120439 494 56877 L412 M P L I Q A A L R K K S I L W
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785170 567 64142 S469 R W K N A T F S Q Y P R P G D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 62 96.9 N.A. N.A. 85.6 20.6 N.A. 68.3 23.6 N.A. 21 N.A. 44.5 44.7 N.A. 48.8
Protein Similarity: 100 65.5 98.5 N.A. N.A. 90.5 36.2 N.A. 78.3 40.9 N.A. 39.8 N.A. 60.9 61.2 N.A. 65.2
P-Site Identity: 100 100 93.3 N.A. N.A. 93.3 13.3 N.A. 66.6 6.6 N.A. 0 N.A. 0 6.6 N.A. 46.6
P-Site Similarity: 100 100 100 N.A. N.A. 100 20 N.A. 86.6 20 N.A. 20 N.A. 6.6 20 N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 55 10 0 10 0 0 10 0 28 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 10 0 19 19 0 0 0 0 0 10 0 0 0 0 46 % D
% Glu: 0 0 37 10 10 0 10 0 0 0 0 0 0 10 0 % E
% Phe: 0 0 10 0 0 0 10 0 0 0 0 19 0 0 10 % F
% Gly: 0 0 0 0 0 0 10 0 0 10 0 0 0 10 0 % G
% His: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 10 % H
% Ile: 0 0 0 10 37 0 0 0 0 10 10 0 10 0 0 % I
% Lys: 0 0 19 0 10 0 0 0 0 10 28 0 10 0 0 % K
% Leu: 10 19 10 46 10 0 0 19 0 0 0 0 0 19 0 % L
% Met: 19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 10 0 0 10 10 10 10 0 0 0 0 0 % N
% Pro: 55 19 10 0 10 10 10 0 0 0 55 10 64 0 0 % P
% Gln: 0 0 0 0 10 0 0 0 55 0 0 0 0 10 0 % Q
% Arg: 10 37 0 0 0 0 0 0 19 0 0 55 0 0 10 % R
% Ser: 0 10 0 0 0 10 0 64 10 0 0 10 19 19 0 % S
% Thr: 0 0 0 10 0 19 0 0 0 0 0 0 0 10 10 % T
% Val: 0 0 0 0 10 0 0 10 0 0 0 0 0 0 10 % V
% Trp: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 10 % W
% Tyr: 0 0 0 0 0 0 46 0 0 55 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _