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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IDS All Species: 9.23
Human Site: T6 Identified Species: 20.31
UniProt: P22304 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22304 NP_000193.1 550 61873 T6 _ _ M P P P R T G R G L L W L
Chimpanzee Pan troglodytes XP_521297 659 72527 T119 A E M P P P R T G R G L P W L
Rhesus Macaque Macaca mulatta XP_001089323 550 61783 S6 _ _ M P T P G S G R G F L W L
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q08890 552 62154 P8 M S P P P P P P I W R Q L S F
Rat Rattus norvegicus P15589 577 62660 L7 _ M L W P C L L A L L L S Q L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512557 523 58748 T6 _ _ M E S Y H T P F D A L P W
Chicken Gallus gallus Q5ZK90 535 61383 L9 G S G G P L L L L R G L L L V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q08CJ7 523 59480 V6 _ _ M L R V F V L L I F N V N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_647814 512 58886
Honey Bee Apis mellifera XP_001120439 494 56877
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785170 567 64142 S6 _ _ M A S H F S L Y A H G M L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 62 96.9 N.A. N.A. 85.6 20.6 N.A. 68.3 23.6 N.A. 21 N.A. 44.5 44.7 N.A. 48.8
Protein Similarity: 100 65.5 98.5 N.A. N.A. 90.5 36.2 N.A. 78.3 40.9 N.A. 39.8 N.A. 60.9 61.2 N.A. 65.2
P-Site Identity: 100 80 69.2 N.A. N.A. 26.6 21.4 N.A. 23 33.3 N.A. 7.6 N.A. 0 0 N.A. 15.3
P-Site Similarity: 100 80 76.9 N.A. N.A. 26.6 28.5 N.A. 23 46.6 N.A. 7.6 N.A. 0 0 N.A. 23
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 10 0 0 0 0 10 0 10 10 0 0 0 % A
% Cys: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % D
% Glu: 0 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 19 0 0 10 0 19 0 0 10 % F
% Gly: 10 0 10 10 0 0 10 0 28 0 37 0 10 0 0 % G
% His: 0 0 0 0 0 10 10 0 0 0 0 10 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 10 0 10 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 10 10 0 10 19 19 28 19 10 37 46 10 46 % L
% Met: 10 10 55 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 10 % N
% Pro: 0 0 10 37 46 37 10 10 10 0 0 0 10 10 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 10 0 10 0 % Q
% Arg: 0 0 0 0 10 0 19 0 0 37 10 0 0 0 0 % R
% Ser: 0 19 0 0 19 0 0 19 0 0 0 0 10 10 0 % S
% Thr: 0 0 0 0 10 0 0 28 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 10 0 10 0 0 0 0 0 10 10 % V
% Trp: 0 0 0 10 0 0 0 0 0 10 0 0 0 28 10 % W
% Tyr: 0 0 0 0 0 10 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 55 46 0 0 0 0 0 0 0 0 0 0 0 0 0 % _